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TranscriptomicsS. pombe acetyltransferase mutants identifies redundant pathways of gene regulation, dual-channel dataset
Analysis of histone acetyl transferases (HATs) from the MYST and GNAT families in S. pombe to identify functional differences or overlap with regard to gene expression. Mutations were made to Elp3 and Gcn5 (GNAT family), and to Mst2 (MYST family). Mutants showed distinct phenotypes which were repres...
ORGANISM(S): Schizosaccharomyces pombe 
2009-09-19 | E-GEOD-17259 | biostudies-arrayexpress
TranscriptomicsGenome structure of radicicol-induced aneuploids in yeast by array CGH
Aneuploidy, a state of having uneven numbers of chromosomes, is a form of large-effect mutation able to confer adaptive phenotypes under diverse stress conditions. Here we investigate whether pleiotropic stresses could in turn induce aneuploidy in budding yeast. Radicicol was shown to induce high l...
ORGANISM(S): Saccharomyces cerevisiae 
2011-12-31 | E-GEOD-34086 | biostudies-arrayexpress
TranscriptomicsKaryotype analysis of radicicol-resistant yeast colonies by array CGH (Radr1,2,3)
Aneuploidy, a state of having uneven numbers of chromosomes, is a form of large-effect mutation able to confer adaptive phenotypes under diverse stress conditions. Here we investigate whether pleiotropic stresses could in turn induce aneuploidy in budding yeast. Cells exposed to radicicol, an Hsp90...
ORGANISM(S): Saccharomyces cerevisiae 
2011-12-31 | E-GEOD-34085 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and myo1 knock out yeast to examine differential gene expression patterns in evolved mutants that can successfully perform cytokinesis
In general, yeast strains with myo1 knocked out cannot perform cytokinesis, but some evolve new ways of accomplishing the task. This is an examination of differential gene expression patterns in a selection of evolved mutants that can successfully perform cytokinesis. The purpose is to attempt a m...
ORGANISM(S): Saccharomyces cerevisiae 
2008-11-24 | E-TABM-559 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast treated with rapamycin in a 7-part time series
This experiment was a 7-part time series (or, 2x7 factorial design) examining the effect of rapamycin on gene expression in Saccharomyces cerevisiae. Treated and untreated cultures were compared at 0, 20, 40, 60, 120, 240, and 360 minutes. In the paper, expression ratios (mRNA) at each time point ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-02-05 | E-TABM-639 | biostudies-arrayexpress
TranscriptomicsRetinoids induce rapid dynamic changes in the non-coding RNAs and epigenetic profiles of murine Hox clusters.
Physiologically relevant concentrations of retinoic acid are added to Mouse ES cells and a time course (0-72 hours) is examined with expression tiling arrays and RNA-seq to characterize the early dynamics of expression of coding and non-coding RNAs in and around the Hox clusters. Gene expression is ...
ORGANISM(S): Mus musculus 
2015-04-27 | E-GEOD-67610 | biostudies-arrayexpress
TranscriptomicsRetinoids induce rapid dynamic changes in the non-coding RNAs and epigenetic profiles of murine Hox clusters (ChIP-chip)
Physiologically relevant concentrations of retinoic acid are added to Mouse ES cells and a time course (0-72 hours) is examined with tiling array ChIP-chip and RNA-seq to characterize the early dynamics of expression of coding and non-coding RNAs and epigenetics in and around the Hox clusters. Expre...
ORGANISM(S): Mus musculus 
2015-04-27 | E-GEOD-61584 | biostudies-arrayexpress
TranscriptomicsRetinoids induce rapid dynamic changes in the non-coding RNAs and epigenetic profiles of murine Hox clusters (tiling)
Physiologically relevant concentrations of retinoic acid are added to Mouse ES cells and a time course (0-72 hours) is examined with expression tiling arrays to characterize the early dynamics of expression of coding and non-coding RNAs in and around the Hox clusters. Gene expression is examined at ...
ORGANISM(S): Mus musculus 
2015-04-27 | E-GEOD-61585 | biostudies-arrayexpress
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