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TranscriptomicsA retrotransposon-driven Dicer variant enhances endogenous RNAi in mouse oocytes
Mammals have one Dicer gene required for biogenesis of small RNAs in microRNA (miRNA) and RNA interference (RNAi) pathways. Yet, endogenous RNAi is highly active in oocytes but not in somatic cells. Here, we provide a mechanistical explanation for high RNAi activity in mouse oocytes. The main Dicer ...
ORGANISM(S): Mus musculus 
2013-11-07 | E-GEOD-41207 | biostudies-arrayexpress
TranscriptomicsEffects of long dsRNA expression in HeLa and HEK293 cells
Double-stranded RNA (dsRNA) can enter different pathways in mammalian cells, including sequence-specific RNA interference, sequence-independent interferon response and editing by adenosine deaminases. To assess the potential of expressed dsRNA to induce interferon stimulated genes in somatic cells, ...
ORGANISM(S): Homo sapiens 
2011-10-10 | E-GEOD-27316 | biostudies-arrayexpress
TranscriptomicsEffects of Dcp1a and Dcp2 knockdown during mouse oocyte maturation
Oocyte maturation is accompanied by a transition from mRNA stability to instability. We investigated the role of DCP1A and DCP2, proteins responsible for mRNA decapping, in mRNA destabilization during mouse oocyte maturation. siRNA-mediated knockdown of both Dcp1a and Dcp2 transcripts prior to ini...
ORGANISM(S): Mus musculus 
2013-02-06 | E-GEOD-27049 | biostudies-arrayexpress
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