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TranscriptomicsA genotype-first approach for the molecular and clinical characterization of uncommon de novo microdeletion of 20q13.33
Molecular cytogenetic techniques such as microarray analysis have allowed for a “genotype-first” approach to the characterization of chromosome abnormalities: in the absence of clinical features suggestive of a specific syndrome, patients with similar copy number imbalances can be examined for commo...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-21536 | biostudies-arrayexpress
TranscriptomicsLeukemia stem cell-enriched population expresses self-renewal gene-expression signature [RNA-Seq]
Mutant RAS oncoproteins activate signaling molecules that drive oncogenesis in multiple human tumors including acute myelogenous leukemia (AML). However, the specific function of these pathways in AML is unclear. To elucidate the downstream functions of activated NRAS in AML, we employed a murine mo...
ORGANISM(S): Mus musculus 
2014-11-14 | E-GEOD-63312 | biostudies-arrayexpress
TranscriptomicsNRASG12V mediates leukemia self renewal [Microarray]
Mutant RAS oncoproteins activate signaling molecules that drive oncogenesis in multiple human tumors including acute myelogenous leukemia (AML). However, the specific function of these pathways in AML is unclear. To elucidate the downstream functions of activated NRAS in AML, we employed a murine mo...
ORGANISM(S): Mus musculus 
2014-11-16 | E-GEOD-49038 | biostudies-arrayexpress
TranscriptomicsNRASG12V mediates leukemia self renewal [RNA-Seq]
Mutant RAS oncoproteins activate signaling molecules that drive oncogenesis in multiple human tumors including acute myelogenous leukemia (AML). However, the specific function of these pathways in AML is unclear. To elucidate the downstream functions of activated NRAS in AML, we employed a murine mo...
ORGANISM(S): Mus musculus 
2014-11-16 | E-GEOD-49088 | biostudies-arrayexpress
TranscriptomicsNRASG12V mediates self renewal in AML [RNA-Seq]
Mutant RAS oncoproteins activate signaling molecules that drive oncogenesis in multiple human tumors including acute myelogenous leukemia (AML). However, the specific function of these pathways in AML is unclear. To elucidate the downstream functions of activated NRAS in AML, we employed a murine mo...
ORGANISM(S): Mus musculus 
2014-11-16 | E-GEOD-49087 | biostudies-arrayexpress
TranscriptomicsGenomic analysis of diffuse pediatric low-grade gliomas identifies recurrent, oncogenic MYBL1-truncating rearrangements
Pediatric low-grade gliomas (PLGGs) are among the most common solid tumors in children but apart from BRAF mutations or duplications in specific subclasses, few genetic driver events are known. Diffuse PLGGs comprise a set of uncommon subtypes that exhibit invasive growth and are therefore especiall...
ORGANISM(S): Homo sapiens 
2013-04-23 | E-GEOD-45843 | biostudies-arrayexpress
TranscriptomicsDesign and use of multiplexed chemostat arrays
We developed and validated a small-footprint array of miniature chemostats built from readily available parts for low cost. Physiological and experimental evolution results were similar to larger volume chemostats. The ministat array provides a compact, inexpensive, and accessible platform for tradi...
ORGANISM(S): Saccharomyces cerevisiae 
2012-12-21 | E-GEOD-36691 | biostudies-arrayexpress
GenomicsAnalysis of whole-genome copy-number variation in Crohn's disease fistula tissue
Background: CrohnM-bM-^@M-^Ys disease is presently an incurable inflammatory bowel disease. Fistulae are extensions of the intestinal tract that may form connections with other organs. These are a common complication of CrohnM-bM-^@M-^Ys disease affecting up to 50% of patients with the most common i...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-44275 | biostudies-arrayexpress
UnknownThe barley MLA13-AVRA13 heterodimer reveals principles for immunoreceptor recognition of RNase-like powdery mildew effectors
Not available
S-SCDT-10_1038-S44318-025-00373-9 | biostudies-other
TranscriptomicsRecurrent 17q23.2 microdeletion flanked by segmental duplications associated with heart defects and limb abnormalities
[original title] Identification of recurrent microdeletion on 17q23.2 flanked by segmental duplications associated with heart defects and limb abnormalities. Segmental duplications, are known to mediate non-allelic homologous recombination and have been suggested to be hotspots in chromosome evolut...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-19932 | biostudies-arrayexpress
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