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TranscriptomicsDifferential RISC association of endogenous human microRNAs predicts their inhibitory potential
It has previously been assumed that the generally high stability of microRNAs (miRNAs) reflects their tight association with Argonaute (Ago) proteins, essential components of the RNA-induced silencing complex (RISC). However, recent data have suggested that the majority of mature miRNAs are not, in ...
ORGANISM(S): Homo sapiens 
2014-05-30 | E-GEOD-58127 | biostudies-arrayexpress
TranscriptomicsDerivation and characterization of Dicer and microRNA deficient human cells
We have used genome editing to generate inactivating deletion mutations in all three copies of the dicer (hdcr) gene present in the human cell line 293T. As previously shown in murine ES cells lacking Dicer function, hDcr-deficient 293T cells are severely impaired for the production of mature microR...
ORGANISM(S): Homo sapiens 
2014-04-17 | E-GEOD-56836 | biostudies-arrayexpress
TranscriptomicsIn depth analysis of the interaction of HIV 1 with cellular microRNA biogenesis and effector mechanisms
The question of how HIV 1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4+ PBMCs and...
ORGANISM(S): Homo sapiens 
2014-07-31 | E-GEOD-59944 | biostudies-arrayexpress
ProteomicsSLC12A3 isoforms in human urine exosomes
The thiazide-sensitive NaCl cotransporter (NCC) is an important pharmacological target in the treatment of hypertension. Human SLC12A3 gene encoding NCC gives rise to three isoforms. Only the isoform 3 has been extensively investigated. The goal of the present study was, therefore, to determine the ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080722 | MassIVE
TranscriptomicsCells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations
Prostate cancer-associated stroma (CAS) plays an active role in malignant transformation, tumor progression, and metastasis. Molecular analyses of CAS have demonstrated significant changes in gene expression; however, conflicting evidence exists on whether genomic alterations in benign cells compris...
ORGANISM(S): Homo sapiens 
2016-02-12 | E-GEOD-76456 | biostudies-arrayexpress
UnknownReducing surgical site infections in low-income and middle-income countries (FALCON): a pragmatic, multicentre, stratified, randomised controlled trial.
Not available
S-EPMC8586736 | biostudies-literature
UnknownAccuracy of the Wound Healing Questionnaire in the diagnosis of surgical-site infection after abdominal surgery in low- and middle-income countries.
Not available
S-EPMC10895408 | biostudies-literature
UnknownAdaptation of the Wound Healing Questionnaire universal-reporter outcome measure for use in global surgery trials (TALON-1 study): mixed-methods study and Rasch analysis.
Not available
S-EPMC10364512 | biostudies-literature
UnknownStructures, processes and outcomes between first referral and referral hospitals in low-income and middle-income countries: a secondary preplanned analysis of the FALCON and ChEETAh randomised trials.
Not available
S-EPMC11552540 | biostudies-literature
UnknownDiscovering HIV related information by means of association rules and machine learning.
Not available
S-EPMC9616424 | biostudies-literature
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