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TranscriptomicsComparative transcriptome analysis of the CO2 sensing pathway via differential expressions of carbonic anhydrase in Cryptococcus neoformans
Carbon dioxide (CO2) sensing, transport, and metabolism play a pivotal role in survival and proliferation of pathogenic microbes infecting human host from natural environments due to the drastic difference of CO2 levels. Carbonic anhydrases (CAs) are not only key CO2-metabolic enzymes catalyzing rev...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2010-05-31 | E-GEOD-21192 | biostudies-arrayexpress
TranscriptomicsRemodeling of global transcription patterns of C. neoformans genes mediated by stress-activated HOG signaling pathways
The ability to sense and adapt to a hostile host environment is a crucial element for virulence of pathogenic fungi, including Cryptococcus neoformans. These cellular responses are evoked by diverse signaling cascades, including the stress-activated HOG pathway. Despite previous analysis of centra...
ORGANISM(S): Cryptococcus neoformans var. grubii 
2010-05-17 | E-GEOD-16692 | biostudies-arrayexpress
TranscriptomicsMolecular and Functional Characterization of the role of RNA silencing components in Cryptococcus neoformans [RNAi_Serotype A]
The RNA interference (RNAi) mediated by homology-dependent degradation of the target mRNA with small RNA molecules plays a key role in controlling transcription and translation processes in a number of eukaryotic organisms. The RNAi machinery is also evolutionarily conserved in a wide variety of fun...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2010-05-01 | E-GEOD-21176 | biostudies-arrayexpress
TranscriptomicsPleiotropic roles of Msi1-like protein, Msl1, in growth, differentiation, stress response, and virulence of Cryptococcus neoformans
WD40 motif-containing Msi1-like (MSIL) proteins play pleiotropic cellular functions as a negative regulator of the Ras/cAMP-pathways and a component of chromatin assembly factor-I (CAF-I), and yet have not been studied in fungal pathogens. Here we identified and characterized an MSIL protein, Msl1, ...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2012-08-23 | E-GEOD-40303 | biostudies-arrayexpress
TranscriptomicsThe bZIP transcription factor Atf1 governs the oxidative stress response and sexual differentiation of Cryptococcus neoformans downstream of the HOG pathway
The high osmolarity glycerol response (HOG) pathway plays a pivotal role in the stress response, virulence regulation, and differentiation of fungi, including Cryptococcus neoformans that causes fatal meningoencephalitis. Core signaling components of in the HOG pathway, including the Tco-Ypd1-Ssk1 p...
ORGANISM(S): Cryptococcus neoformans var. grubii 
2015-01-13 | E-GEOD-64871 | biostudies-arrayexpress
TranscriptomicsDelta-mbs1 mutant
A family of APSES transcription factor is known to be fungal-specific transcriptional regulators and play important roles in governing growth, differentiation, and virulence of diverse fungal pathogens. Yet none of APSES-like transcription factors have been identified and investigated in a basidiomy...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2011-06-23 | E-GEOD-30156 | biostudies-arrayexpress
TranscriptomicsToc1, Toc2, and Skn7 null mutants treated with Flucytosine
A family of APSES transcription factor is known to be fungal-specific transcriptional regulators and play important roles in governing growth, differentiation, and virulence of diverse fungal pathogens. Yet none of APSES-like transcription factors have been identified and investigated in a basidiomy...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2011-06-23 | E-GEOD-30154 | biostudies-arrayexpress
TranscriptomicsMolecular and Functional Characterization of the role of RNA silencing components in Cryptococcus neoformans [RNAi_Serotype D]
The RNA interference (RNAi) mediated by homology-dependent degradation of the target mRNA with small RNA molecules plays a key role in controlling transcription and translation processes in a number of eukaryotic organisms. The RNAi machinery is also evolutionarily conserved in a wide variety of fun...
ORGANISM(S): Cryptococcus neoformans var. neoformans JEC21 
2010-05-01 | E-GEOD-21177 | biostudies-arrayexpress
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