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Effect of different profiles of fluid flow-induced shear stress application on MAPK pathway gene expression in human mesenchymal stem cells
ORGANISM(S): Homo sapiens 
Renal epithelial cells are exposed to mechanical forces due to flow-induced shear stress within the nephrons. We applied RNA sequencing to get a comprehensive overview of fluid-shear regulated genes and pathways in the immortalized renal proximal tubular epithelial cell line. Cells were exposed to l...
ORGANISM(S): Mus musculus 
Pkd1-/- renal epithelial cells are exposed to mechanical forces due to flow-induced shear stress within the nephrons. We applied RNA sequencing to get a comprehensive overview of fluid-shear regulated genes and pathways in the immortalized Pkd1-/- renal proximal tubular epithelial cell line. Cells w...
ORGANISM(S): Mus musculus 
Tissue Factor Pathway Inhibitor-2 is Induced by Fluid Shear Stress in Vascular Smooth Muscle Cells and Affects Cell Proliferation and Survival Introduction: Vascular smooth muscle cells (SMCs) are exposed to fluid shear stress (FSS) after interventional procedures such as balloon-angioplasty. Wher...
ORGANISM(S): Rattus norvegicus 
Cyclic mechanical loads applied to the skeleton increase bone formation. Dynamic fluid flow is a potent anabolic stimulus for cultured osteoblasts. In this study, gene profiles involved in mediating the anabolic response of MC3T3 osteoblasts to dynamic fluid flow are investigated. MC3T3 osteoblast R...
ORGANISM(S): Mus musculus 
P300 Modulates Endothelial Mechanotransduction of Fluid Shear Stress
Lymphatic valves are specialized units regularly distributed along collecting vessels that allow unidirectional forward propulsion of the lymph, and its efficient transport from tissues to the bloodstream. Lymphatic endothelial cells that cover lymphatic valve sinuses are subjected to complex flow p...
ORGANISM(S): Homo sapiens 
Andrew Koo, David Nordsletten, Renato Umeton, Beracah Yankama, Shiva Ayyadurai, Guillermo García-Cardeña & C. Forbes Dewey. In silico modeling of shear-stress-induced nitric oxide production in endothelial cells through systems biology. Biophysical Journal 104, 10 (2013). Nitric oxide (NO) produced...
2024-09-02 | BIOMD0000000468 | BioModels
Andrew Koo, David Nordsletten, Renato Umeton, Beracah Yankama, Shiva Ayyadurai, Guillermo García-Cardeña & C. Forbes Dewey. In silico modeling of shear-stress-induced nitric oxide production in endothelial cells through systems biology. Biophysical Journal 104, 10 (2013). Nitric oxide (NO) produced...
2024-09-02 | BIOMD0000000466 | BioModels
Andrew Koo, David Nordsletten, Renato Umeton, Beracah Yankama, Shiva Ayyadurai, Guillermo García-Cardeña & C. Forbes Dewey. In silico modeling of shear-stress-induced nitric oxide production in endothelial cells through systems biology. Biophysical Journal 104, 10 (2013). Nitric oxide (NO) produced...
2024-09-02 | BIOMD0000000467 | BioModels
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