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GenomicsExtra centrosomes delay DNA damage-driven tumorigenesis
Centrosomes act as microtubule organizing centers and are critical for faithful chromosome segregation in mitosis. Deregulated centrosome numbers are frequently found in human cancer and can promote malignancies in model organisms. Current research aims to clarify if extra centrosomes are cause or c...
ORGANISM(S): Mus musculus 
2026-01-22 | E-MTAB-13724 | biostudies-arrayexpress
TranscriptomicsChromosome copy number changes in Mps1DK-driven p53 null T-ALL samples
Mps1DK and p53 loss were combined in T-cells specificely leading to early onset and highly aggressive aneuploid T-ALL. Tumors were characterized for (recurrrent) copy number changes with a focus on whole chromosome abnormalities. DNA content was compared to the DNA content of sex-matched uninfiltrat...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-57331 | biostudies-arrayexpress
TranscriptomicsTranscriptional response to aneuploidy in mouse epidermis
Analysis of the transcriptional response to aneuploidy in mouse epidermis. In this study we measured the transcriptional response to aneuploidy by aboragting the spindle checkpoint in mouse epidermis. We found that, whereas spindle checkpoint inactivation in the epidermis is tolerated, but results i...
ORGANISM(S): Mus musculus 
2013-01-22 | E-GEOD-42698 | biostudies-arrayexpress
ProteomicsIFNγ protects motor neurons from oxidative stress via enhanced global protein synthesis in FUS-associated Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis type 6 (ALS6) is a familial subtype of ALS linked to Fused in Sarcoma (FUS) gene mutation. FUS mutations lead to decreased global protein synthesis, but the mechanism that drives this has not been established. Here, we used ALS6 patient-derived induced pluripotent stem ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD038042 | Pride
Als  als6  fus  protein synthesis  ifny 
UnknownHigh CDC20 levels increase sensitivity of cancer cells to MPS1 inhibitors
Not available
S-SCDT-10_1038-S44319-024-00363-8 | biostudies-other
UnknownChromosomal instability promotes cell migration and invasion via EFEMP1 in extracellular vesicles
Not available
S-SCDT-10_1038-S44318-026-00766-4 | biostudies-other
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