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MetabolomicsNuclear Magnetic Resonance-Based Blood Metabolic Profiles of Rats Exposed to Short-Term Caloric Restriction
Caloric restriction increases life-span of a number of organisms. The relationship between the increase in life-span and the extent of caloric restriction, however, varies among species. The underlying mechanisms are yet unknown, but appear to be related to changes in metabolism. In order to investi...
2014-09-05 | MTBLS114 | MetaboLights
MetabolomicsA high-fiber diet mimics aging-related signatures of caloric restriction in mammals

Caloric restriction (CR) delays aging-related hallmarks in various organisms by slowing growth and development while enhancing metabolic homeostasis. However, desirable diets that harness the metabolic benefits of CR without imposing food intake restrictions remain elusive. Here we evaluated the ...

2025-06-13 | MTBLS12479 | MetaboLights
MetabolomicsNon-canonical Metabolic and Molecular Effects of Calorie Restriction Are Revealed by Varying Temporal Conditions

Calorie restriction (CR) extends lifespan and healthspan in diverse species. However, comparing ad libitum (AL) and CR-fed mice is challenging due to their significantly different feeding patterns. CR-fed mice consume their daily meal in approximately 2 hours, subjecting themselves to a prol...

2025-07-07 | MTBLS10795 | MetaboLights
MetabolomicsProlonged fasting times reap greater geroprotective effects when combined with caloric restriction in adult female mice
Emerging new evidence highlights the importance of prolonged daily fasting periods for the health and survival benefits of calorie restriction (CR) and time-restricted feeding (TRF) in male mice; however, little is known about the impact of these feeding regimens in females. We placed 14-month-old f...
2024-05-14 | MTBLS790 | MetaboLights
TranscriptomicsLeptin and the Placental Response to Maternal Food Restriction during Early Pregnancy
Concentrations of leptin decline during food restriction. This study was designed to test the hypothesis that some of the effects of maternal food restriction on placental development are mediated by the loss of leptin. Mice were randomized to 3 treatment groups on day 1.5 of pregnancy: (1) ad libi...
ORGANISM(S): Mus musculus 
2012-12-07 | E-GEOD-38095 | biostudies-arrayexpress
MetabolomicsGut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice
Calorie restriction (CR) and fasting are common approaches to weight reduction, but the maintenance is difficult after resuming food consumption. Meanwhile, the gut microbiome associated with energy harvest alters dramatically in response to nutrient deprivation. Here, we reported that CR and high-f...
2022-04-01 | MTBLS4431 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAMPT targeted therapy)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7252 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAD targeted time-course)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7253 | MetaboLights
TranscriptomicsSeeking genes responsible for developmental origins of health and disease (DOHaD) from the fetal mouse brain following maternal food deprivation (FD) and food restriction (FR) using OMICS approach
A non-optimal fetal environment is known to cause low birth weight, which has been epidemiologically associated with a greater risk of adult diseases. Maternal undernutrition in animal models has also revealed the increased risks for adult diseases in the offspring. In this study, pregnant mice unde...
ORGANISM(S): Mus musculus 
2015-09-19 | E-GEOD-73202 | biostudies-arrayexpress
ProteomicsQuantitative proteomics of rat livers shows that unrestricted feeding and re-feeding after food restriction are stressful for cellular proteostasis
We used quantitative MS-based proteomic analysis of whole rat livers to study the molecular events associated with a food restriction regimen as compared with ad libitum food and animals re-fed after a restriction time.
ORGANISM(S): Rattus norvegicus (Rat) 
2016-12-23 | PXD004068 | Pride
Food restriction Liver Rat Food intake Label-free 
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