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TranscriptomicsThe stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression
Transcriptional profiling of control and MKK7-deficient primary mouse pneumocytes after oncogenic KRasG12 induction Two-condition experiment, MKK7 proficient vs. MKK7 deficient pneumocytes. 3 Biological replicates: 3 control, 3 knock out, independently grown and harvested. 3 technical replicates p...
ORGANISM(S): Mus musculus 
2011-01-21 | E-GEOD-26763 | biostudies-arrayexpress
TranscriptomicsThe TLR2 pathway is required for self-renewal of mammary cancer initiating cells
In the past few years, mammary cancer initiating cells (CICs) have been identified in mouse and human as a subpopulation of tumor cells that selectively posses tumor initiation and self-renewal capacity and the ability to give rise to bulk populations of non-tumorigenic cancer cells progeny through ...
ORGANISM(S): Mus musculus 
2013-11-30 | E-GEOD-26527 | biostudies-arrayexpress
TranscriptomicsFrom mouse to humans: detecting preventing vaccination targets associated to breast cancer stem cells
The efficacy of cancer treatments have improved constantly in the last decade. However, therapeutic resistance and the lack of curative treatments in metastatic disease, raises the question if conventional anticancer therapies target the right cells. Indeed, these treatments might miss cancer stem c...
ORGANISM(S): Mus musculus 
2013-11-30 | E-GEOD-21486 | biostudies-arrayexpress
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