This is a case-control study of alcoholism, in which the subjects have been drawn from the Collaborative Study on the
Genetics of Alcoholism (COGA), a large, ongoing family-based study that includes subjects from seven sites around the US.
COGA has gathered detailed, standardized data on ...
This is a case-control study of alcoholism, in which the subjects have been drawn from the Collaborative Study on the
Genetics of Alcoholism (COGA), a large, ongoing family-based study that includes subjects from seven sites around the US.
COGA has gathered detailed, standardized data on ...
Multiplex Family Study The purpose of the NIA Genetics Initiative: Multiplex Family Study is to identify families with
multiple members diagnosed with late-onset Alzheimer's Disease. Families will be characterized clinically and blood samples will be
collected to establish cell...
Alzheimer disease is the most common neurodegenerative disorder of the elderly affecting an estimated five million Americans. Genetic factors contribute to the risk for disease with heritability estimates ranging from 57% to 79%. More than a decade ago, the ε4 variant of APOE was identif...
This study is part of the Gene Environment Association Studies initiative (GENEVA) funded by the National Human Genome Research Institute. The overarching goal is to identify novel genetic factors that contribute to addiction through a large-scale genome-wide association study of DSM-IV alcoh...
Our long-term objective is to identify susceptibility genes that are related to the formation of intracranial aneurysms (IA). Rupture of IAs occurs in 16,000 to 17,000 persons in the U.S. annually and nearly half of affected persons are dead within the first 30 days. An additional 6,000 to 7,000 ...
This proposal brings together the two largest NIH funded genetic studies focused on the identification of novel genes that
influence the risk of PD. These two studies, PROGENI (PI: Tatiana Foroud; R01NS037167) and GenePD (PI: Richard Myers; R01NS036711)
have been evaluating and recruiti...
We have an ongoing study that has recruited families having at least a sibling pair with Parkinson disease (PD). Families have been screened for mutations in known PD causative genes (LRRK2, parkin, etc). Following review of families without a causative mutation, we selected families for ...
The goal of this study is to identify the genes underlying the risk of intracranial aneurysm (IA). The FIA Study initially recruited families appropriate for linkage analysis. Therefore, the recruitment focus was not only on probands with a family history of IA but also required that biological s...
