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TranscriptomicsExpression profiling of S. pombe acetyltransferase mutants identifies redundant pathways of gene regulation
Analysis of histone acetyl transferases (HATs) from the MYST and GNAT families in S. pombe to identify functional differences or overlap with regard to gene expression. Mutations were made to Elp3 and Gcn5 (GNAT family), and to Mst2 (MYST family). Mutants showed distinct phenotypes which were repres...
ORGANISM(S): Schizosaccharomyces pombe 
2009-09-19 | E-GEOD-17298 | biostudies-arrayexpress
TranscriptomicsComparative Dynamic Transcriptome Analysis (cDTA) reveals mutual feedback between mRNA synthesis and degradation
Data was pre-processed array-wise using expresso (R/Bioconductor) with the RMA background correction method. We created our own probe annotation environment (cdf), which excludes probes in probesets that show cross-hybridization between Sc and Sp. 8708 annotated Sc probes and 13,317 annotated Sp pro...
ORGANISM(S): Schizosaccharomyces pombe 
2012-03-28 | E-MTAB-760 | biostudies-arrayexpress
TranscriptomicsArchitecture of the RNA polymerase II-Mediator core transcription initiation complex
Comparative Dynamic Transcriptome Analysis (cDTA) enables global analysis of newly synthesized RNA as described in Sun et al. Genome Res. 2012 (DOI:10.1101/gr.130161.111) and reveals defects in transcription with much higher sensitivity than conventional steady-state methods. cDTA was carried out a...
ORGANISM(S): Saccharomyces cerevisiae S288c 
2015-02-04 | E-MTAB-2942 | biostudies-arrayexpress
TranscriptomicsGlobal analysis of mRNA degradation reveals Xrn1-dependent buffering of transcript levels
The rates of mRNA synthesis and degradation determine cellular mRNA levels and can be monitored by comparative Dynamic Transcriptome Analysis (cDTA) that uses non-perturbing metabolic RNA labeling. Here we present cDTA data for 46 yeast strains lacking genes involved in mRNA degradation and metaboli...
ORGANISM(S): Schizosaccharomyces pombe 
2013-10-18 | E-MTAB-1525 | biostudies-arrayexpress
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