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TranscriptomicsDifferentiation of human monocytes to macrophages in the presence of GM-CSF +/- forskolin (FSK)
Macrophages are central mediators of the innate immune system that can be differentiated from monocytes upon exposure to cytokines. While increased cyclic adenosine monophosphate (cAMP) levels inhibit many lipopolysaccharide (LPS) -elicited macrophage inflammatory responses, the effects of elevated ...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-18654 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Schwann cells after extended exposure to heregulin and forskolin
Schwann cells, expanded in number by exposure to growth factors in vitro, could be useful in nervous system repair. Our previous results suggest that long term exposure to heregulin and forskolin changes the functional properties of the human Schwann cells, including the ability to myelinate axons a...
ORGANISM(S): Homo sapiens 
2007-06-22 | E-GEOD-4030 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of forskolin-synchronized NIH3T3 cells to detect rhythmic transcripts
High-temporal resolution profiling was performed on NIH3T3 fibroblasts to detect rhythmic transcripts Experiment Overall Design: Samples were collected every hour for 48 hours from forskolin-synchronized NIH3T3 cells. Samples were analyzed using Affymetrix arrays.
ORGANISM(S): Mus musculus 
2008-10-26 | E-GEOD-11922 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of chicken quiescent and proliferating auditory epithelia
In order to gain insight into the molecular events which underlie auditory hair cell regeneration in chicken, we compared gene expression in chicken basilar papillae after 24, 48, and 72 hours in culture with or without forskolin (100uM).

Under sterile conditions, cochlear ducts containing th...
ORGANISM(S): Gallus gallus 
2010-06-09 | E-MEXP-2642 | biostudies-arrayexpress
TranscriptomicsSerial analysis of chromatin occupancy (SACO) of forskolin-induced mRNA vs. an inactive control in the rat PC12 cell pheochromocytoma cell line to identify CREB targets
PC12 cells (passage 22) were cultured at 5% CO2 in a 37 C incubator. The growth medium was DMEM (high glucose, Invitrogen) supplemented with 25mM HEPES, 10% FCS, 5% FBS and 1x Pen/Strep (Invitrogen). 1x10^6 cells were starved overnight in DMEM +25 mM HEPES and treated with 10 uM 1,9 dideoxy forskoli...
ORGANISM(S): Rattus norvegicus 
2007-09-18 | E-GEOD-2071 | biostudies-arrayexpress
TranscriptomicsEffect of cholera toxin or forskolin on mouse bone marrow-derived dendritic cells
Bone marrow-derived dendritic cells from C57BL/6 mice were treated with 1 ug/ml cholera toxin, 10 uM forskolin or control medium for 2 h. drug treatment groups
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21711 | biostudies-arrayexpress
TranscriptomicsExpression data of mouse NIH3T3 and NIH3T3-k-ras transformed cell lines after Forskolin treatment
Forskolin treatment induces activation of protein kinase A. This activation protects transformed cells from death induced by glucose starvation. We used microarray to identify the mechanisms involved in such a pro-survival effect. NIH3T3 and NIH3T3-K-ras were plated at 1mM glucose and then daily tre...
ORGANISM(S): Mus musculus 
2015-10-24 | E-GEOD-68266 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of SIK2 regulated genes and pathways
Identification of SIK2 regulated genes and pathways after SIK2 knock-down and overexpression of a wild-type and kinase-dead SIK2. The hypothesis is that SIK2 regulated gene expression via CREB1 Total RNAs were obtained after SIK2 gene was knocked down with siRNA and after a wild-type SIK2 or a kinas...
ORGANISM(S): Homo sapiens 
2015-01-12 | E-GEOD-45711 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HEK 293 cells with or without overexpression of the repressor ICER treated by forskolin at 0,1,2,4 and 8 hours
HEK 293 cells with or without overexpression of ICER IIg were treated with forskolin for 0, 1 h, 2 h, 4 h or 8 h. The cell line used in the experiments is HEK 293 cells stable transfected with tetracycline-inducible ICER (Inducible cAMP early repressor) expression.
ORGANISM(S): Homo sapiens 
2010-01-01 | E-MTAB-122 | biostudies-arrayexpress
TranscriptomicsForskolin induction of fusion in BeWo trophoblast cells
Trophoblast fusion is a central step in placental physiology. This mechanisms can be studied in the BeWO cell model that fuse following forskolin treatment that activates the c-AMP cascade.
ORGANISM(S): Homo sapiens 
2020-12-16 | E-MTAB-9832 | biostudies-arrayexpress
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