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TranscriptomicsChromatin occupancy and target genes of TCF7L2 in hepatocytes
TCF7L2 regulates multiple metabolic pathways in hepatocytes through a transcriptional network involving HNF4M-NM-1 For the identification of Tcf7l2 target genes using a RNA-seq timecourse, and for identifying the binding sites of Tcf7l2 and Hnf4a, Tcf7l2 was silenced in rat H4IIE hepatocytes using s...
ORGANISM(S): Rattus norvegicus 
2014-11-24 | E-GEOD-53862 | biostudies-arrayexpress
UnknownFurther evidence supporting a potential role for ADH1B in obesity.
Not available
S-EPMC7820614 | biostudies-literature
UnknownIncreased lipid availability for three days reduces whole body glucose uptake, impairs muscle mitochondrial function and initiates opposing effects on PGC-1α promoter methylation in healthy subjects.
Not available
S-EPMC5737973 | biostudies-literature
UnknownThe mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells.
Not available
S-EPMC4267646 | biostudies-literature
UnknownThe Insulin-Sensitizer Pioglitazone Remodels Adipose Tissue Phospholipids in Humans.
Not available
S-EPMC8674727 | biostudies-literature
UnknownSex-dependent adipose glucose partitioning by the mitochondrial pyruvate carrier.
Not available
S-EPMC11118482 | biostudies-literature
UnknownThe Diabetes Gene and Wnt Pathway Effector TCF7L2 Regulates Adipocyte Development and Function.
Not available
S-EPMC5860863 | biostudies-literature
GenomicsChromatin occupancy of TCF7L2 in hepatocytes
TCF7L2 is one of the strongest type 2 diabetes (T2DM) candidate genes to emerge from GWAS studies, but the mechanisms by which it regulates the pathways which are important in the pathogenesis of type 2 diabetes are unknown. Previous in vitro and in vivo studies have focused on the link between TCF7...
ORGANISM(S): Rattus norvegicus 
2011-09-12 | E-GEOD-28782 | biostudies-arrayexpress
UnknownInsulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease.
Not available
S-EPMC7811046 | biostudies-literature
UnknownThe mitochondrial pyruvate carrier regulates adipose glucose partitioning in female mice.
Not available
S-EPMC11382204 | biostudies-literature
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