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UnknownDouble-Blind Phase III Trial of Adjuvant Chemotherapy With and Without Bevacizumab in Patients With Lymph Node-Positive and High-Risk Lymph Node-Negative Breast Cancer (E5103).
Not available
S-EPMC6118403 | biostudies-literature
TranscriptomicsEffect of transgenic human IL8 on gene expression in mouse colon cancer tumors
mRNA expression in colon cancer tumores of CBA/C57BL/6 transgenic mice bearing a BAC which contains the human IL8 gene and promoter was compared to that of CBA/C57BL/6 controls. A. CBA/C57BL/6 mice controls (n=3) B. human IL8 transgenic CBA/C57BL/6 mice (n=3).
ORGANISM(S): Mus musculus 
2013-01-11 | E-GEOD-39273 | biostudies-arrayexpress
UnknownNivolumab for Metastatic Renal Cell Carcinoma: Results of a Randomized Phase II Trial.
Not available
S-EPMC4806782 | biostudies-literature
TranscriptomicsEffect of Tff2 on mouse Gr1+Cd11b+
The gene expression of murine splenic myeloid derived suppressor cells treated with Tff2 is characterized. The motivation of the study originates in the fact that Gr1+Cd11b+ myeloid-derived suppressor cells (MDSCs), which resemble immature myeloid cells (IMCs), expand during cancer in response to in...
ORGANISM(S): Mus musculus 
2016-05-30 | E-GEOD-47596 | biostudies-arrayexpress
TranscriptomicsExpression of MERTK based on Multiple Sclerosis (MS) risk haplotype
Whole transcriptome RNA-seq analysis to measure group-wise RNA expression level of the MERTK gene in 3 healthy controls (known to be homozygous non-risk haplotype at MERTK gene locus) and to compare this to the group-wise RNA expression level of the MERTK gene in 5 Multiple Sclerosis-affected (MS-af...
ORGANISM(S): Homo sapiens 
2016-02-06 | E-GEOD-77598 | biostudies-arrayexpress
TranscriptomicsPhasevarion of non-typeable Haemophilus influenzae R2866
H. influenzae R2866 contains a phase-variable DNA methylase modA10, by virtue of 16 tetrameric repeats present after the start codon. Gain or loss of repeats during replication by slipped-strand mispairing can result in a non-functional reading frame. Microarray analyses of wild-type and insertional...
ORGANISM(S): Haemophilus influenzae R2866 
2015-09-24 | E-GEOD-73349 | biostudies-arrayexpress
TranscriptomicsCarbon Redistribution from Surface Lipids into Triacylglycerols in Leaves of Arabidopsis by Introducing a Chlamydomonas Diacylglycerol Acyltransferase 2
Plants and microalgae have the ability to harness sunlight into energy dense molecules such as triacylglycerols (TAGs). TAGs hold great importance for human and animal nutrition, and are also a source for renewable energy. Acyl-CoA-dependent TAG synthesis by diacylglycerol acyltransferases (DGATs) i...
ORGANISM(S): Arabidopsis thaliana 
2014-06-16 | E-GEOD-38898 | biostudies-arrayexpress
TranscriptomicsmRNA expression data from mice infected with H. pylori treated with estradiol, tamoxifen, or placebo
We are investigating the mRNA expression profiles of gastric tissue within H. pylori-infected mice treated with estradiol, tamoxifen, or placebo We used microarrays to compare the global mRNA expression profiles in H. pylori infected mice in response to estradiol and tamoxifen Male mice were infecte...
ORGANISM(S): Mus musculus 
2011-06-30 | E-GEOD-29715 | biostudies-arrayexpress
GenomicsFGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency
Genome-wide erasure of DNA methylation takes place in primordial germ cells (PGCs) and early embryos but the signalling mechanisms that induce reprogramming are unknown. Here we show that inhibition of Erk1/2 and Gsk3bM-BM- signalling in mouse embryonic stem cells (ESCs) by small molecule inhibitors...
ORGANISM(S): Mus musculus 
2013-06-27 | E-GEOD-42923 | biostudies-arrayexpress
TranscriptomicsMapping and dynamics of regulatory DNA and transcription factor networks in A. thaliana
We mapped DNaseI hypersensitive sites (DHSs) and applied genomic footprinting to define in vivo transcription factor (TF) occupancy at nucleotide resolution across the A. thaliana genome in whole seedlings during heat- and light-response states. We find that trait-associated variation localizes with...
ORGANISM(S): Arabidopsis thaliana 
2013-12-15 | E-GEOD-53322 | biostudies-arrayexpress
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