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TranscriptomicsThe FoxO signature in protein breakdown
Under stress conditions mammalian cells activate compensatory mechanisms to survive and maintain cellular function. During catabolic conditions, such as low nutrients, systemic inflammation, cancer or infections, protein breakdown is enhanced and aminoacids are released from muscles to sustain liver...
ORGANISM(S): Mus musculus 
2015-04-24 | E-GEOD-52667 | biostudies-arrayexpress
MetabolomicsMetabolomic analysis of C2C12 myoblasts induced by the transcriptional factor FOXO1
Not available
ORGANISM(S): Mus musculus 
ST001178 | MetabolomicsWorkbench
TranscriptomicsExpression data from U2OS ER-E2F1 cells after FOXO knockdown and E2F1 activation
Effect of FOXO knockdown on E2F1-mediated transcription U2OS cells stably expressing ER-E2F1 were infected with two different lentiviruses both targeting FOXO1 and FOXO3 or control virus encoding scrambled sequence. Twenty four hours post infection medium was replaced to serum-free DMEM for 24 hour...
ORGANISM(S): Homo sapiens 
2012-07-05 | E-GEOD-39136 | biostudies-arrayexpress
TranscriptomicsFoxo1/3-deficient Treg cells
Identification of Foxos target genes in Treg cells. Foxo1and Foxo3 are transcription factors of Foxo family. CD4+Foxp3+ Treg cells isolated from wild-type and Foxo1/3-deficient mice were analyzed by global gene expression profiling. Results indicate Foxos regulate expression of a subset of Treg cell...
ORGANISM(S): Mus musculus 
2010-09-13 | E-GEOD-21678 | biostudies-arrayexpress
GenomicsFoxo signaling declines with age
Foxo signaling declines with age
PRJNA505319 | ENA
TranscriptomicsGenome-wide Analysis of Class IIa Histone Deacetylase Regulation of Hepatic Gluconeogenesis
Analysis of Class II Histone Deacetylase (HDAC) regulation of hepatic gluconeogenesis at the gene expression level. We show that in liver, Class IIa HDACs (HDAC4, 5, and 7) are all phosphorylated and excluded from the nucleus by AMPK family kinases. In response to the fasting hormone glucagon, Class...
ORGANISM(S): Mus musculus 
2011-09-08 | E-GEOD-20979 | biostudies-arrayexpress
Transcriptomicsdaf-16/FoxO isoform-specific deletion mutants
FoxO transcription factors promote longevity across taxa. How they do so is poorly understood. In the nematode Caenorhabditis elegans, the A- and F-isoforms of the FoxO transcription factor DAF-16 extend life span in the context of reduced DAF-2 insulin-like growth factor receptor (IGFR) signaling. ...
ORGANISM(S): Caenorhabditis elegans 
2015-08-27 | E-GEOD-72426 | biostudies-arrayexpress
TranscriptomicsExpression data from skeletal muscles of flies with muscle-specific overexpression of Foxo or Mnt
Skeletal muscle senescence influences whole organism aging, yet little is known on the relay of pro-longevity signals from muscles to other tissues. We performed an RNAi screen in Drosophila for muscle-released cytokines ('myokines') regulating lifespan and identified Myoglianin, the homolog of huma...
ORGANISM(S): Drosophila melanogaster 
2014-07-02 | E-GEOD-39877 | biostudies-arrayexpress
ModelsSmith2010 - Response of FOXO Transcription Factors to Post-Translational Modifications (with acetylation pathway)
Graham R. Smith & Daryl P. Shanley. Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways. PLoS ONE 5, 6 (2010). FOXO transcription factors are an important, conserved family of regulators of cellular processes i...
2024-09-02 | BIOMD0000000706 | BioModels
TranscriptomicsDAF-16/FoxO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage [N2, daf-2, daf-16, daf-2;daf-16]
Genome maintenance defects cause complex disease phenotypes characterized by developmental failure, cancer susceptibility and premature aging. It remains poorly understood how DNA damage responses function during organismal development and maintain tissue functionality when DNA damage accumulates wi...
ORGANISM(S): Caenorhabditis elegans 
2014-11-18 | E-GEOD-51162 | biostudies-arrayexpress
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