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GenomicsDerivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations
The presence of two active X chromosomes (XaXa) is a hallmark of the ground state of pluripotency specific to murine embryonic stem cells (ESCs). Human ESCs invariably exhibit signs of X chromosome inactivation (XCI) and are considered developmentally more advanced than their murine counterparts. W...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-21141 | biostudies-arrayexpress
TranscriptomicsStem cell coculture
This study aims to to compare the gene transcription profiles of endothelial cells and stem cells, when they are cultured alone or when they are cultured together. Thus there are two major questions - how do the cells differ, and how do the cells influence each other's gene expression. ...
ORGANISM(S): Homo sapiens 
2013-10-10 | E-MTAB-1536 | biostudies-arrayexpress
TranscriptomicsDerivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations
The presence of two active X chromosomes (XaXa) is a hallmark of the ground state of pluripotency specific to murine embryonic stem cells (ESCs). Human ESCs invariably exhibit signs of X chromosome inactivation (XCI) and are considered developmentally more advanced than their murine counterparts....
ORGANISM(S): Homo sapiens 
2010-11-10 | E-GEOD-20937 | biostudies-arrayexpress
Genomicsena-DATASET-ICR-PTGT-28-07-2015-16:51:33:172-264 - samples
Anaplastic oligodendrogliomas (AOs) are rare primary brain tumors which are generally incurable, with heterogeneous prognosis and few treatment targets identified. Most oligodendrogliomas have chromosome 1p/19q co-deletion and IDH mutation. We analyzed 51 AOs by whole-exome sequencing, identifying p...
EGAD00001001452 | EGA
GenomicsAnaplastic oligodendroglioma exome and RNA sequencing data
Anaplastic oligodendrogliomas (AOs) are rare primary brain tumors which are generally incurable, with heterogeneous prognosis and few treatment targets identified. Most oligodendrogliomas have chromosome 1p/19q co-deletion and IDH mutation. We analyzed 51 AOs by whole-exome sequencing, identifying p...
EGAS00001001209 | EGA
GenomicsMolecular and Population Genetics (MPG) research at ICR DAC and POLA DAC
Data Access Committee EGAC00001000328
EGAC00001000328 | EGA
TranscriptomicsSenescent and myofibroblastic cancer-associated fibroblasts share a contractile phenotype regulated by NOX4 generation of reactive oxygen species in the tumour microenvironment
Cancer associated fibroblasts characterized by an myofibroblastic phenotype play a major role in the tumour microenvironment, being associated with poor prognosis. We found that this cell population is made in part by senescent fibroblasts in vivo. As senescent fibroblasts and myofibroblasts have be...
ORGANISM(S): Homo sapiens 
2017-06-01 | E-MTAB-3101 | biostudies-arrayexpress
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