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TranscriptomicsMicroarray Quality Control Study 2, Neuroblastoma one-color
This set of profiles was utilized to construct, validate and evaluate a gene-expression based classifier of outcome of neuroblastoma patients
ORGANISM(S): Homo sapiens 
2010-12-31 | E-MTAB-179 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat neonatal ventricular cardiomyocytes (NRVCMs) stretched biaxially (112%/24h) or stimulated with phenylephrine (PE, 50 uM
Neonatal rat ventricular cardiomyocytes (NRVCMs) were stretched biaxially (112%/24h) or stimulated with phenylephrine (PE, 50 uM), both resulting in a similar degree of hypertrophy. Unstretched NRVCMs served as negative control. Affymetrix microarray analysis revealed 164 genes more than 2.0-fold up...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-5996 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of neuroblastoma tumors with and without MYCN amplification
Purpose: Clinical courses of neuroblastomas (NBs) range from rapid progression with fatal outcome despite intensive multimodality therapies to spontaneous regression. Amplified MYCN oncogene defines a subgroup with poor outcome. However, a substantial number of MYCN single-copy NBs exhibits an aggre...
ORGANISM(S): Homo sapiens 
2007-06-01 | E-CVDE-2 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neuroblastoma cells with and without MYCN oncogene induction and doxorubicin treatment
Purpose: Clinical courses of neuroblastomas (NBs) range from rapid progression with fatal outcome despite intensive multimodality therapies to spontaneous regression. Amplified MYCN oncogene defines a subgroup with poor outcome. However, a substantial number of MYCN single-copy NBs exhibits an aggre...
ORGANISM(S): Homo sapiens 
2007-06-01 | E-CVDE-3 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of D34+ BCR-ABL+ cells of CML patients in chronic phase or blast crisis to identify differentially expressed stage-specific genes
Profiling CD34+ BCR-ABL+ cells of CML patients in chronic phase or blast crisis to identify differentially expressed stage-specific genes.
ORGANISM(S): Homo sapiens 
2006-08-08 | E-MEXP-480 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human chromic myeloid leukemia (CML) patients treated second-line with imatinib after failure of an interferon-alpha based therapy to identify genes with predictive value for primary cytogenetic outcome to imatinib
Identification of genes in CML patients with predictive value for their primary cytogenetic outcome to imatinib. All samples analyzed were taken just before the start of imatinib treatment. Leukemic patients were treated second-line with imatinib after failure of an interferon-alpha based therapy (f...
ORGANISM(S): Homo sapiens 
2006-05-31 | E-MEXP-433 | biostudies-arrayexpress
Genomicsena-DATASET-DKFZ-IBIOS-29-08-2014-08:27:40:831-1015 - samples
Whole-exome sequencing of a chronic lymphocytic leukemia (CLL) developed during vemurafenib treatment of a patient with malignant melanoma. Peripheral blood mononuclear cells were separated by Ficoll gradient centrifugation. DNA was extracted from highly purified (>97%) CD19+CD5+ cells obtained from...
EGAD00001000997 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-28-05-2015-11:13:32:451-82 - samples
Mutations that activate the RAF-MEK-ERK signaling pathway, in particular BRAFV600E, occur in many cancers, and mutant BRAF-selective inhibitors have clinical activity in these diseases. Activating BRAF alleles are usually considered to be mutually exclusive with mutant RAS, whereas inactivating muta...
EGAD00001001384 | EGA
TranscriptomicsTranscription profling of human neuroblastoma samples to construct, validate and evalute a gene expression based classification of outcome of treatment
This set of 320 profiles was utilized to construct, validate and evaluate a gene-expression based classifier of outcome of neuroblastoma patients
ORGANISM(S): Homo sapiens 
2009-02-17 | E-TABM-38 | biostudies-arrayexpress
GenomicsDKFZ-HIPO Project H021/NCT MASTER
Clinical genome and transcriptome sequencing in younger adults with advanced-stage cancer across all histologies: DKFZ-HIPO Project H021 (http://www.hipo-heidelberg.org/hipo2/index.php/menu-item-2/32-021-prospective-genetic-characterization-of-tumors-from-individual-patients-of-special-interest) / N...
EGAS00001000948 | EGA
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