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GenomicsHaploinsufficiency of an RB-E2F1-Condensin II complex causes replication stress and contributes to mesenchymal cancers [CAP-D3 localization]
Genome instability is a characteristic of malignant cells, however, evidence for its contribution to tumorigenesis has been enigmatic. In this study we demonstrate that a complex containing the retinoblastoma protein, E2F1, and Condensin II localizes to major satellite repeats at pericentromeres. In...
ORGANISM(S): Mus musculus 
2014-06-19 | E-GEOD-55040 | biostudies-arrayexpress
GenomicsHaploinsufficiency of an RB-E2F1-Condensin II complex causes replication stress and contributes to mesenchymal cancers [γH2AX localization]
Genome instability is a characteristic of malignant cells, however, evidence for its contribution to tumorigenesis has been enigmatic. In this study we demonstrate that a complex containing the retinoblastoma protein, E2F1, and Condensin II localizes to major satellite repeats at pericentromeres. In...
ORGANISM(S): Mus musculus 
2014-06-19 | E-GEOD-51558 | biostudies-arrayexpress
TranscriptomicsHaploinsufficiency of an RB-E2F1-Condensin II complex causes replication stress and contributes to mesenchymal cancers [CGH]
Genome instability is a characteristic of malignant cells, however, evidence for its contribution to tumorigenesis has been enigmatic. In this study we demonstrate that a complex containing the retinoblastoma protein, E2F1, and Condensin II localizes to major satellite repeats at pericentromeres. In...
ORGANISM(S): Mus musculus 
2014-06-19 | E-GEOD-51876 | biostudies-arrayexpress
UnknownHIV-1 DNA predicts disease progression and post-treatment virological control.
Not available
S-EPMC4199415 | biostudies-literature
TranscriptomicsHistone deacetylase inhibition replicates aspects of the adaptive response to exercise and improves muscle metabolism and cardiac function in obesity.
Drugs used to treat obesity and type 2 diabetes have limited efficacy in directly normalising muscle metabolism. The discovery of molecules mediating exercise adaptations, and drugs that modulate their activity, is a potential strategy to address this therapeutic gap. Here we show that genetic impai...
ORGANISM(S): Mus musculus 
2015-01-28 | E-GEOD-54642 | biostudies-arrayexpress
UnknownThe effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial.
Not available
S-EPMC3145073 | biostudies-literature
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