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UnknownPhase I Study of Single-Agent AZD1775 (MK-1775), a Wee1 Kinase Inhibitor, in Patients With Refractory Solid Tumors.
Not available
S-EPMC4606059 | biostudies-literature
UnknownAllogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host Disease.
Not available
S-EPMC4872017 | biostudies-literature
TranscriptomicsHigh throughput sequencing of immunoglobulin (Ig) heavy (IgH) and light (IgL) chain repertoires
We used 454 sequencing to assess the repertoire of B cell subsets from bone marrow, spleen, and small intestinal lamina propria from two mouse strains. We used a RAG2-GFP reporter mouse strain (129Sve background) to isolate CD19+ RAG2+ B lineage cells from bone marrow and small intestinal lamina pro...
ORGANISM(S): Mus musculus 
2013-07-16 | E-GEOD-48870 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profile in RAG2+ B lineage cells from the small intestinal lamina propria and RAG2+ B lineage cells from the bone marrow
We used a RAG2-GFP reporter mouse to show that RAG+ B lineage cells can be found in the small intestinal lamina proria in normally-housed mice at weaning age. We used microarry expression analysis to compare the RAG2+ population in the gut to the RAG2+ B lineage population in the bone marrow. Microa...
ORGANISM(S): Mus musculus 
2013-07-12 | E-GEOD-48805 | biostudies-arrayexpress
UnknownT Cells Genetically Modified to Express an Anti-B-Cell Maturation Antigen Chimeric Antigen Receptor Cause Remissions of Poor-Prognosis Relapsed Multiple Myeloma.
Not available
S-EPMC6067798 | biostudies-literature
UnknownImpact of age on outcomes after initial therapy with chemotherapy and different chemoimmunotherapy regimens in patients with chronic lymphocytic leukemia: results of sequential cancer and leukemia group B studies.
Not available
S-EPMC3731920 | biostudies-literature
UnknownNKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer.
Not available
S-EPMC9479122 | biostudies-literature
TranscriptomicsEndogenous Elevation of Homocysteine Induces Retinal Neuron Death in the Cystathionine-b-Synthase Mutant Mice
The effects of endogenous elevation of homocysteine on retinal gene expression were screened by microarray analysis, which was performed in triplicate (i.e., three different paired RNA samples) with RNA isolated from neural retinas of cbs+/- HM at 5-weeks after a methionine diet and age-matched wild...
ORGANISM(S): Mus musculus 
2014-04-04 | E-GEOD-56458 | biostudies-arrayexpress
TranscriptomicsLong Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells
Repair of DNA double-strand breaks (DSBs) by non-homologous end-joining is critical for neural development, and brain cells frequently contain somatic genomic variations that might involve DSB intermediates. We now use an unbiased, high-throughput approach to identify genomic regions harboring recur...
ORGANISM(S): Mus musculus 
2016-02-15 | E-GEOD-74356 | biostudies-arrayexpress
TranscriptomicsDeletion of the Mammalian INDY Homologue in Mice Mimics Aspects of Dietary Restriction and Protects Against Diet and Age-Induced Adiposity and Insulin Resistance
Reduction in expression of the INDY gene in Drosophila melanogaster and Caenorhabditis elegans prolongs life span, and in D. melanogaster augments mitochondrial biogenesis in a manner akin to caloric restriction. However, the cellular mechanism by which INDY does this is unknown. In order to examine...
ORGANISM(S): Mus musculus 
2011-08-03 | E-GEOD-29984 | biostudies-arrayexpress
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