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UnknownSLCO2B1 and SLCO1B3 may determine time to progression for patients receiving androgen deprivation therapy for prostate cancer.
Not available
S-EPMC3138634 | biostudies-literature
TranscriptomicsToxicogenomic Responses to Inorganic and Organic Mercury in Caenorhabditis elegans
Humans are exposed to both inorganic and organic mercury. While the toxicity of mercury is well established, much remains to be resolved about how different mercurials act at the molecular level. To address this issue, we employed a toxicogenomics approach using the nematode C. elegans. Using sub...
ORGANISM(S): Caenorhabditis elegans 
2013-09-09 | E-GEOD-28915 | biostudies-arrayexpress
TranscriptomicsRNA expression at chromosome 8q24 in human colon
An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that this region is a transcriptional enhancer, that the risk region physically interacts with the MYC proto-oncogene, and that the alleles of rs6983267 differentially bind t...
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-16228 | biostudies-arrayexpress
TranscriptomicsFunctional enhancers at the gene-poor 8q24 cancer-linked locus
Multiple discrete regions at 8q24 were recently shown to contain alleles that predispose to many cancers including prostate, breast, and colon. These regions are far from any annotated gene and their biological activities have been unknown. Here we profiled a 5-megabase chromatin segment encompassin...
ORGANISM(S): Homo sapiens 
2009-12-18 | E-GEOD-19561 | biostudies-arrayexpress
GenomicsA Multiethnic Genome wide Scan of Prostate Cancer

Multiple GWA studies of prostate cancer conducted in European White populations are ongoing. These studies will continue to have a dramatic impact on our understanding of the contribution of common genetic variation on inter-individual susceptibility to this common cancer. Important questions tha...

phs000306.v3.p1 | EGA
TranscriptomicsCross-platform comparability of microarray data
To facilitate collaborative research efforts between multi-investigator teams using DNA microarrays, we identified sources of error and data variability between laboratories and across microarray platforms and methods to accommodate this variability. RNA expression data were generated in seven labo...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-2458 | biostudies-arrayexpress
GenomicsCell Type Specific Enrichment Of Risk Associated Regulatory Elements At Ovarian Cancer Susceptibility Loci
Understanding the regulatory landscape of the human genome is a central question in complex trait genetics. Most single nucleotide polymorphisms (SNPs) associated with cancer risk lie in non protein-coding regions, implicating regulatory DNA elements as functional targets of susceptibility variants....
ORGANISM(S): Homo sapiens 
2015-04-22 | E-GEOD-68104 | biostudies-arrayexpress
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