H3K4me3 occupancy profiles were generated for wild-type mESCs using the CUT&RUN assay. Matched non-targeting IgG samples were included as negative controls to ensure specificity of enrichment.
To identify novel susceptibility loci for psoriasis, we undertook a genome-wide association scan of of 594,224 SNPs in 2,622 individuals with psoriasis and 5,667 controls.