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to find out the lnc122(precursor of miR-122) role as an independent lncRNA, we designed the lnc122-/miR-122+ Huh7 cells with Lenti-CRISPRi_lnc122 + lenti-CAG-miR-122 combination. lenti-CRISPRi_lnc122 suppresses endogenous lnc122 as well as miR-122 but we add back the miR-122 ectopically.
ORGANISM(S): Homo sapiens 
The formation of inflammatory foamy macrophages hinders brain repair in multiple sclerosis. Therefore, the phenotype of the macrophages can determine the repair status of brain lesions. Here, we established the impact of the general S-palmitoylation inhibitor 2BP on the phenotype of bone marrow-deri...
ORGANISM(S): Mus musculus 
Human blood vessel organoids (hBVOs) have emerged as a system to model human vascular development and disease. Here, we use genetic and signaling pathway perturbations to reconstruct hBVO development. We use single-cell genetic perturbations to identify transcription factors (TFs) and receptors invo...
ORGANISM(S): Homo sapiens 
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