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TranscriptomicsEvaluation of a New High-Dimensional miRNA Profiling Platform
We evaluated a new miRNA profiling platform that utilizes Illumina’s existing robust DASL chemistry as the basis for the assay. Using total RNA from five colon cancer patients and four cell lines, we evaluated the reproducibility of miRNA expression levels across replicates and with varying amoun...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-17346 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of mouse Gata1- megakaryocyte-erythroid progenitors (G1MEs) expressing one of the two isoforms of GATA1: full-length (GATA1fl) or an amino-truncated form of GATA1 (GATA1s).
We transduced mouse Gata1- megakaryocyte-erythroid progenitors with MIGRI-GFP vector expressing GATA1fl or GATA1s cDNAs. GFP-positive cells expressing one of the two isoforms of GATA1 were isolated by FACS 42 hours following transduction and used for microarray transcriptome analysis. At this time p...
ORGANISM(S): Mus musculus 
2015-01-26 | E-GEOD-62879 | biostudies-arrayexpress
GenomicsGenome wide association scan in Parkinson's disease
Genome-wide association scan was performed in 1,705 cases of parkinson's genotyped on the Illumina Human 660W SNP array, and 5,175 controls genotyped on the Illumina1.2M-Duo. Analysis was carried out on the overlaps set of SNPs.
EGAS00000000034 | EGA
GenomicsPD
WTCCC project samples from the Parkinson's disase cohort
EGAD00000000057 | EGA
TranscriptomicsTranscription profiling of human filaria induced monocyte dysfunction and its reversal following treatment
To assess the function of peripheral blood derived monocytes in patently infected filaria patients (either Wuchereria bancrofti, Mansonella perstans, or both), we investigated the cytokine production and gene expression profile of these cells in filaria infected patients and compared them with those...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2135 | biostudies-arrayexpress
TranscriptomicsFT1 and FT2 network analysis in poplar
We conducted microarray experiments by comparing constitutive and inducible Flowering Locus T1 (FT1) and FT2 constructs with appropriate controls, followed by the identification of common targets of Pro35S:FT1 and ProHSP:FT1 or Pro35S:FT2 and ProHSP:FT2. Independent samples of leaf tissues were coll...
ORGANISM(S): Populus tremula x Populus tremuloides 
2011-05-23 | E-GEOD-24609 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of trisomy 21 and euploid iPSC-derived hematopoietic progenitors expressing wtGATA1 or an amino-truncated isoform of GATA1, GATA1short (GATA1s).
We generated human induced pluripotent stem cells (iPSCs) from trisomy 21 (T21) and euploid patient tissues with and without GATA1 mutations causing exclusive expression of truncated GATA1, termed GATA1short (GATA1s). Transcriptome analysis comparing expression levels of genes in GATA1s vs. wtGATA1-...
ORGANISM(S): Homo sapiens 
2015-01-26 | E-GEOD-36787 | biostudies-arrayexpress
GenomicsXist exploits three-dimensional chromosome architecture to spread across the X-chromosome
Many large noncoding RNAs (lncRNAs) regulate chromatin, but the mechanisms by which they localize to genomic targets remain unexplored. Here we investigate the localization mechanisms of Xist during X-chromosome inactivation (XCI), a paradigm of lncRNA-mediated chromatin regulation. During the maint...
ORGANISM(S): Mus musculus 
2013-05-30 | E-GEOD-46918 | biostudies-arrayexpress
GenomicsGenome-wide binding analysis of GATA1fl and GATA1s in G1ME cells.
We used chromatin immunoprecipitation sequencing (ChIP-seq) to compare genome-wide binding profiles of GATA1fl and GATA1s in G1ME cells, which are immortalized, developmentally arrested megakaryocyte-erythroid progenitors (MEPs) derived from in vitro differentiation of murine Gata1- ES cells. Althou...
ORGANISM(S): Mus musculus 
2015-01-26 | E-GEOD-61932 | biostudies-arrayexpress
ProteomicsCouzens_Hippo_P86_VS4
Not available
2013-06-28 | MSV000078450 | MassIVE
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