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TranscriptomicsDifferentiation of NUT midline carcinoma by epigenomic reprogramming
Knockdown of the oncogene, BRD4-NUT, in a rare cancer, termed NUTmidline carcinoma (NMC), results in morphologic features consistent with squamous differentiation. Treatment with the HDAC-inhibitor, TSA, appears to cause the same phenotype. Here, we use gene expression profiling to compare the cha...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-18668 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of mouse embryonic stem cells during retinoic acid-induced differentiation
Changes in microRNA expression profile during retinoic acid-induced differentiation of mouse embryonic stem cells.
ORGANISM(S): Mus musculus 
2007-04-01 | E-MEXP-977 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses to Sonic Hedgehog pathway stimulation in in vitro derived neural progenitors
The objective of this study was to identify genes regulated by Sonic Hedgehog pathway stimulation in neural progenitors. Paired (parallel culture) triplicates of neuralized embryoid body cultures with and without Shh pathway stimulation (Ag1.3-treatment)
ORGANISM(S): Mus musculus 
2012-12-15 | E-GEOD-42565 | biostudies-arrayexpress
TranscriptomicsIdentification of recurrent GBM patients that may benefit from Bevacizumab and CCNU: A report from the BELOB trial by the Dutch Neurooncology Group
The results from the randomized phase II BELOB trial provided evidence for a potential benefit of bevacizumab (beva; a humanized monoclonal antibody against circulating VEGF-A) when added to CCNU chemotherapy in recurrent GBM patients. In this study, we have performed gene expression profiling (DASL...
ORGANISM(S): Homo sapiens 
2016-01-19 | E-GEOD-72951 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of embryoid bodies treated with retinoic-acid or retinoic-acid + hedgehog agonist to measure neural targets of sonic hedgehog signaling
This experiment was specifically designed to measure neural targets of Shh signaling, we sought to profile the genes upregulated by Hh signaling in the ventral neural tube to obtain a valid dataset. To obtain ventral-specific markers, we generated retinoic acid-treated EBs grown in the presence or ...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-4936 | biostudies-arrayexpress
GenomicsChIP-seq analysis of Gli1 and Sox2 input to neural progenitor program and integration with actve histone marks
In the vertebrate neural tube, regional Sonic hedgehog (Shh) signaling invokes a time- and concentration-dependent induction of six different cell populations mediated through Gli transcriptional regulators. Elsewhere in the embryo, Shh/Gli responses invoke different tissue appropriate regulatory pr...
ORGANISM(S): Mus musculus 
2012-12-15 | E-GEOD-42132 | biostudies-arrayexpress
GenomicsPD
WTCCC project samples from the Parkinson's disase cohort
EGAD00000000057 | EGA
GenomicsGenome wide association scan in Parkinson's disease
Genome-wide association scan was performed in 1,705 cases of parkinson's genotyped on the Illumina Human 660W SNP array, and 5,175 controls genotyped on the Illumina1.2M-Duo. Analysis was carried out on the overlaps set of SNPs.
EGAS00000000034 | EGA
TranscriptomicsMaternal inhalation of surface-coated nano-sized titanium dioxide (UV-Titan): Effects in prenatally exposed offspring on hepatic DNA damage and gene expression
In the present study we investigate the effect of maternal pulmonary exposure to titanium dioxide (UV-Titan designed for use in the paint and lacquer industry) on prenatally exposed offspring. Time-mated mice (C57BL/6BomTac) were exposed by inhalation for 1 h/day to 42 mg UV-titan/m3 aerosolized pow...
ORGANISM(S): Mus musculus 
2012-03-19 | E-GEOD-29067 | biostudies-arrayexpress
TranscriptomicsmRNAseq analysis of Nkx2.2, Nkx6.1, and Olig2 overexpression in neural progenitors
Nkx2.2, Nkx6.1, and Olig2 repressors were overexpressed, singly or in combination, in in vitro-derived mouse neural progenitors to identify thier repression targets Overexpression study to identify genes repressed by Nkx2.2, Nkx6.1, and Olig2 in neural progenitors
ORGANISM(S): Mus musculus 
2015-08-24 | E-GEOD-65457 | biostudies-arrayexpress
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