Sort   by:  
 Page size 
TranscriptomicsOpposing effects of estrogen and Runx2 on breast cancer cell proliferation: identification of a reciprocally-regulated gene signature with clinical prognostic value.
Analysis of reciprocal modulation of Runx2 and E2 signaling in BCA. Our objective was to investigate whether the interaction between estrogen and Runx2 signaling in breast cancer (BCa) could help refine an estrogen-responsive gene signature with improved prognostic value. MCF7/Rx2dox BCa cells condi...
ORGANISM(S): Homo sapiens 
2012-03-06 | E-GEOD-30597 | biostudies-arrayexpress
GenomicsGenome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion.
Runx2 is a metastatic transcription factor (TF) increasingly expressed during prostate cancer (PCa) progression. Using PCa cells conditionally expressing Runx2, we previously identified Runx2-regulated genes with known roles in epithelial-mesenchymal transition, invasiveness, angiogenesis, extracel...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-33889 | biostudies-arrayexpress
TranscriptomicsRUNX2 selectively attenuates or augments androgen-driven transcription in prostate cancer
Prostate carcinogenesis is associated with changes in androgen signaling from driving cellular differentiation to promoting oncogenic behaviors. RUNX2 binds the androgen receptor (AR), and ectopic expression of RUNX2 is linked to prostate cancer (PCa) progression. We therefore investigated genome-...
ORGANISM(S): Homo sapiens 
2014-03-20 | E-GEOD-52627 | biostudies-arrayexpress
GenomicsBreast Cancer Suppressor Role of RUNX1: Estrogen-dependent Regulation of AXIN1 and b-catenin
The transcription factor RUNX1 exhibits recurrent loss-of-function mutations in estrogen receptor-positive (ER+) breast cancer (BCa). Its knockdown in vitro decreased AXIN1 expression in estrogen-dependent manner. Consistently, RUNX1 and AXIN1 mRNA levels are strongly correlated in ER+, not ER- tu...
ORGANISM(S): Homo sapiens 
2016-02-22 | E-GEOD-65313 | biostudies-arrayexpress
UnknownADHD Symptoms in Post-Institutionalized Children Are Partially Mediated by Altered Frontal EEG Asymmetry.
Not available
S-EPMC5374053 | biostudies-literature
TranscriptomicsFunctional enhancers at the gene-poor 8q24 cancer-linked locus
Multiple discrete regions at 8q24 were recently shown to contain alleles that predispose to many cancers including prostate, breast, and colon. These regions are far from any annotated gene and their biological activities have been unknown. Here we profiled a 5-megabase chromatin segment encompassin...
ORGANISM(S): Homo sapiens 
2009-12-18 | E-GEOD-19561 | biostudies-arrayexpress
TranscriptomicsRunx2 Transcriptome of Prostate Cancer Cells: Insights into Invasiveness and Bone Metastasis
Background: Prostate cancer (PCa) cells preferentially metastasize to bone at least in part by acquiring osteomimetic properties. Runx2, an osteoblast master transcription factor, is aberrantly expressed in PCa cells, and promotes their metastatic phenotype. The transcriptional programs regulated by...
ORGANISM(S): Homo sapiens 
2010-12-26 | E-GEOD-24261 | biostudies-arrayexpress
Sort   by:  
 Page size