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TranscriptomicsTranscriptome-based profiling reveals a macrophage pedigree and identifies Irf8 as pivotal for macrophage homeostasis and function
Recent studies have shown that tissue macrophages (MF) arise from embryonic progenitors of the yolk sac (YS) and fetal liver and colonize the tissues before birth. Further studies have proposed that developmentally distinct tissue MF can be identified based on the differential expression of F4/80 an...
ORGANISM(S): Mus musculus 
2016-07-28 | E-GEOD-73125 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis to evaluate the function of USP18 in the mouse CNS
Microglia are tissue macrophages of the central nervous system (CNS) that control tissue homeostasis, and as such they are crucially important for organ integrity. Microglia dysregulation is thought to be causal for a group of neuropsychiatric, neurodegenerative and neuroinflammatory diseases, calle...
ORGANISM(S): Mus musculus 
2015-04-20 | E-GEOD-61499 | biostudies-arrayexpress
ProteomicsIdentification of tumor antigens among the HLA peptidomes of Glioblastoma tumors and plasma
Glioblastoma multiforme (GBM) is the most aggressive brain tumor with poor prognosis to most patients. Immunotherapy of GBM is a potentially beneficial treatment option, whose optimal implementation may depend on familiarity with tumor specific antigens, presented as HLA peptides by the GBM cells. F...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084343 | MassIVE
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