Sort   by:  
 Page size 
TranscriptomicsRole of AhR in thymocyte emigration in vivo
Over-activation of the aryl hydrocarbon receptor by TCDD in mice leads among other phenotypes to a severe thymic atrophy accompanied by immunosuppression. TCDD causes a block in thymocyte maturation and a preferential emigration of immature CD4-CD8- DN thymocytes (recent thymic emigrants) into the p...
ORGANISM(S): Mus musculus 
2008-11-25 | E-GEOD-10166 | biostudies-arrayexpress
TranscriptomicsEffect of an AhR-/- on transcription in CD4 T cells from the spleen.
CD4+ T cells from 8-12 week female mice were isolated from wt and AhR-/- mice 24h after injection of 10µg/kg TCDD or solvent control. Keywords: TCDD, AHR, immunosuppression Each experiment was performed in biological duplicates from 4 pooled animals. Since TCDD treatment showed only marginal impac...
ORGANISM(S): Mus musculus 
2008-11-25 | E-GEOD-10084 | biostudies-arrayexpress
TranscriptomicsEffect of TCDD Exposure on purified splenic CD8 T cells
8-12 week, female C57BL/6 mice were injected with 10 µg/kg TCDD or solvent control. CD8+ T cells from spleen were FACS purified and submitted to transcription profiling Keywords: TCDD, AHR, Immunosupression peripheral T cells, CD8 T cells, Toxicogenomics For each group 4 female C57BL/6 mice were tre...
ORGANISM(S): Mus musculus 
2008-11-25 | E-GEOD-10093 | biostudies-arrayexpress
TranscriptomicsAHR mediated gene expression changes in immature DN thymocytes and thymic emigrants
Effect of an immunosupressive dose of TCDD, a ligand for the aryl hydrocarbon receptor, on the gene expression profile of fetal DN thymocytes and thymic emigrants C57BL6 mice were mated and the pregnant dams sacrifice at day 15 of gestation. Fetal thymic lobes were prepared and cultured for 6 days o...
ORGANISM(S): Mus musculus 
2008-11-25 | E-GEOD-13720 | biostudies-arrayexpress
TranscriptomicsTCDD induced gene expression changes in dendritic cells
Effect of the over activation of the aryl hydrocarbon receptor on gene expression of spleen derived dendritic cells. 8-12 week old, female C57BL6 mice were injected 10 µg/kg TCDD i.p. or solvent control. After 24 h mice were sacrificed and splenic dendritic cells purified by MACS sorting.
ORGANISM(S): Mus musculus 
2008-11-25 | E-GEOD-13719 | biostudies-arrayexpress
TranscriptomicsAhR activation by TCDD in the ET, cortical epithelial cell line
Over activation of the aryl hydrocarbon receptor (AhR) by TCDD results ampng other phenotypes in severe thymic atrophy accompanied by immunosuppression. The link between thymic atrophy, skewed thymocyte differntiation and immunosuppression is still not fully resolved. This study investigates the TCD...
ORGANISM(S): Mus musculus 
2008-12-30 | E-GEOD-10168 | biostudies-arrayexpress
Sort   by:  
 Page size