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TranscriptomicsGenome position and gene amplification - expressional profiling of methotrexate resistant colonies
We investigated the influence of genome position on propensity to amplify. First, we integrated a mutant form of DHFR into different positions in the human genome, challenged cells with methotrexate and then studied the genomic alterations arising in drug resistant cells. We observed site specific d...
ORGANISM(S): Homo sapiens 
2007-10-08 | E-GEOD-6361 | biostudies-arrayexpress
TranscriptomicsCopy number profiling of 92 human lung tumors on Affymetrix 100K SNP arrays
Copy number profiling of 92 human lung tumors on Affymetrix 100K SNP arrays was conducted in order to assess the interaction of common genomic alterations with response to targeted anti-cancer therapeutics. Class 1 phosphatidylinositol 3' kinase (PI3K) plays a major role in cell proliferation and su...
ORGANISM(S): Homo sapiens 
2013-01-10 | E-GEOD-39793 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel
Array comparative genomic hybridization characterization and comparison of cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel.
ORGANISM(S): Homo sapiens 
2005-11-23 | E-TABM-65 | biostudies-arrayexpress
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