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UnknownThe Bank Vole (Clethrionomys glareolus)-Small Animal Model for Hepacivirus Infection.
Many people worldwide suffer from hepatitis C virus (HCV) infection, which is frequently persistent. The lack of efficient vaccines against HCV and the unavailability of or limited compliance with existing antiviral therapies is problematic for health care systems worldwide. Improved small animal mo...
S-EPMC8708279 | biostudies-literature
UnknownThe transcriptional co-activator Yap1 promotes adult hippocampal neural stem cell activation.
Most adult hippocampal neural stem cells (NSCs) remain quiescent, with only a minor portion undergoing active proliferation and neurogenesis. The molecular mechanisms that trigger the transition from quiescence to activation are still poorly understood. Here, we found the activity of the transcripti...
S-EPMC10233373 | biostudies-literature
UnknownModiDeC: a multi-RNA modification classifier for direct nanopore sequencing.
RNA modifications play a crucial role in various cellular functions. Here, we present ModiDeC, a deep-learning-based classifier able to identify and distinguish multiple RNA modifications (N6-methyladenosine, inosine, pseudouridine, 2'-O-methylguanosine, and N1-methyladenosine) using direct RNA sequ...
S-EPMC12276011 | biostudies-literature
UnknownEST based phylogenomics of Syndermata questions monophyly of Eurotatoria.

Background

The metazoan taxon Syndermata comprising Rotifera (in the classical sense of Monogononta+Bdelloidea+Seisonidea) and Acanthocephala has raised several hypotheses connected to the phylogeny of these animal groups and the included subtaxa. While the monophyletic origin of Syndermata ...
S-EPMC2654452 | biostudies-literature
UnknownShikonin Inhibits Cell Growth of Sunitinib-Resistant Renal Cell Carcinoma by Activating the Necrosome Complex and Inhibiting the AKT/mTOR Signaling Pathway.
Therapy resistance remains a major challenge in treating advanced renal cell carcinoma (RCC), making more effective treatment strategies crucial. Shikonin (SHI) from traditional Chinese medicine has exhibited antitumor properties in several tumor entities. We, therefore, currently investigated SHI's...
S-EPMC8909272 | biostudies-literature
UnknownGlobal metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress.

Background

Metabolic adaptations can allow cancer cells to survive DNA-damaging chemotherapy. This unmet clinical challenge is a potential vulnerability of cancer. Accordingly, there is an intense search for mechanisms that modulate cell metabolism during anti-tumor therapy. We set out to de...
S-EPMC9251592 | biostudies-literature
UnknownExtracting the Auditory Attention in a Dual-Speaker Scenario From EEG Using a Joint CNN-LSTM Model.
Human brain performs remarkably well in segregating a particular speaker from interfering ones in a multispeaker scenario. We can quantitatively evaluate the segregation capability by modeling a relationship between the speech signals present in an auditory scene, and the listener's cortical signals...
S-EPMC8365753 | biostudies-literature
UnknownNuclear Egress Complexes of HCMV and Other Herpesviruses: Solving the Puzzle of Sequence Coevolution, Conserved Structures and Subfamily-Spanning Binding Properties.
Herpesviruses uniquely express two essential nuclear egress-regulating proteins forming a heterodimeric nuclear egress complex (core NEC). These core NECs serve as hexameric lattice-structured platforms for capsid docking and recruit viral and cellular NEC-associated factors that jointly exert nucle...
S-EPMC7354485 | biostudies-literature
UnknownFew Amino Acid Exchanges Expand the Substrate Spectrum of Monocarboxylate Transporter 10.
Monocarboxylate transporters (MCTs) belong to the SLC16 family within the major facilitator superfamily of transmembrane transporters. MCT8 is a thyroid hormone transporter mutated in the Allan-Herndon-Dudley syndrome, a severe psychomotor retardation syndrome. MCT10 is closely related to MCT8 and i...
S-EPMC5426580 | biostudies-literature
ProteomicsHydration status of geriatric patients is associated with changes of serum proteome especially of proteins involved in coagulation
Due to multifactorial reasons, such as decreased thirst and decreased total body water, elderly patients are vulnerable to dehydration. The study aims to investigate whether moderate dehydration or hyperhydration affects the blood proteome. Blood samples, medication and bioelectrical impedance analy...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD043728 | Pride
Dehydration Alzheimer Wound healing Hyperhydration Serum Coagulation Dementia Tmt Human Biomarker Tandem mass tags 
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