Sort   by:  
 Page size 
TranscriptomicsAltering cancer transcriptomes using epigenomic inhibitors [RNA-Seq]
We have compared the genome-wide effects on the transcriptome after treatment with ICG-001 (the specific CBP inhibitor) versus C646, a compound that competes with acetyl-coA for the Lys-coA binding pocket of both CBP and p300. We found that both drugs cause large-scale changes in the transcriptome o...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-63776 | biostudies-arrayexpress
GenomicsGenomic targets of the KRAB and scan domain-containing zinc finger protein 263 (ZNF263).
Half of all human transcription factors use C2H2 zinc finger domains to specify site-specific DNA binding and yet very little is known about their role in gene regulation. Based on in vitro studies, a zinc finger code has been developed that predicts a binding motif for a particular zinc finger fact...
ORGANISM(S): Homo sapiens 
2009-12-03 | E-GEOD-19235 | biostudies-arrayexpress
GenomicsZNF274 colocalizes with the histone methyltransferase SETDB1 at ZNF 3' ends.
Only a small percentage of human transcription factors (e.g. those associated with a specific differentiation program) are expressed in a given cell type. Thus, cell fate is mainly determined by cell type-specific silencing of transcription factors that drive different cellular lineages. Several hi...
ORGANISM(S): Homo sapiens 
2010-11-15 | E-GEOD-24632 | biostudies-arrayexpress
GenomicsCell type-specific binding patterns reveal that TCF7L2 can be tethered to the genome by association with GATA3
The TCF7L2 transcription factor is linked to a variety of human diseases, including type 2 diabetes and cancer. One mechanism by which TCF7L2 could influence expression of genes involved in diverse diseases is by binding to distinct regulatory regions in different tissues. To test this hypothesis, ...
ORGANISM(S): Homo sapiens 
2012-06-05 | E-GEOD-38447 | biostudies-arrayexpress
TranscriptomicsGlobal analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with Eralpha
Background: The ZNF217 gene, encoding a C2H2 zinc finger protein, is located at 20q13 and found amplified and overexpressed in greater than 20% of breast tumors. Current studies indicate ZNF217 drives tumorigenesis, yet the regulatory mechanisms of ZNF217 are largely unknown. Because ZNF217 associat...
ORGANISM(S): Homo sapiens 
2014-06-15 | E-GEOD-58326 | biostudies-arrayexpress
TranscriptomicsAltering cancer transcriptomes using epigenomic inhibitors
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-64039 | biostudies-arrayexpress
TranscriptomicsAltering cancer transcriptomes using epigenomic inhibitors [Illumina beadchip]
We have compared the genome-wide effects on the transcriptome after treatment with ICG-001 (the specific CBP inhibitor) versus C646, a compound that competes with acetyl-coA for the Lys-coA binding pocket of both CBP and p300. We found that both drugs cause large-scale changes in the transcriptome o...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-64038 | biostudies-arrayexpress
TranscriptomicsSelective Functions of Individual Zinc Fingers Within the DNA-Binding Domain of Ikaros
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-09-08 | E-GEOD-33693 | biostudies-arrayexpress
Sort   by:  
 Page size