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TranscriptomicsThe hypoxia-inducible transcription factor ZNF395 is controlled by I-kappaB kinase and activates genes involved in the innate immune response and cancer
Activation of the hypoxia inducible transcription factor HIF-alpha and the NF-kappaB pathway promotes inflammation mediated tumor progression. The cellular transcription factor ZNF395 was repeatedly found over expressed in various human cancers and particularly in response to hypoxia, implying a fun...
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-44327 | biostudies-arrayexpress
TranscriptomicsActivating transcription factor 3 regulates immune and metabolic homeostasis
Integration of metabolic, stress and immune responses plays a fundamental role during animal development to maintain energy homeostasis while ensuring growth and proper developmental timing. Perturbation of metabolic and immune signaling circuits has detrimental consequences to animal development in...
ORGANISM(S): Drosophila melanogaster 
2012-11-05 | E-GEOD-36377 | biostudies-arrayexpress
TranscriptomicsEts-domain transcription factor Ets21c and nuclear receptor Ftz-F1 are novel effectors of JNK promoting tumor malignancy
Cancer represents a complex family of diseases, characterized by the uncontrolled malignant growth of a particular cell type and by metastatic dissemination of these transformed cells to secondary sites. The hallmark tumor features emerge as a result of aberrant cellular signaling and pathological g...
ORGANISM(S): Drosophila melanogaster 
2015-11-04 | E-GEOD-65261 | biostudies-arrayexpress
TranscriptomicsDAF-16/FoxO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage [N2, daf-2, daf-16, daf-2;daf-16]
Genome maintenance defects cause complex disease phenotypes characterized by developmental failure, cancer susceptibility and premature aging. It remains poorly understood how DNA damage responses function during organismal development and maintain tissue functionality when DNA damage accumulates wi...
ORGANISM(S): Caenorhabditis elegans 
2014-11-18 | E-GEOD-51162 | biostudies-arrayexpress
TranscriptomicsIdentification of differentially regulated genes in flcn-1 mutant C. elegans
Birt-Hogg-Dubé syndrome is an autosomal dominantly inherited disorder that is characterized by the clinical triad of benign skin tumors - so-called fibrofolliculomas, recurrent pneumothoraces due to pulmonary cysts and the formation of kidney tumors. The molecular function of Folliculin (FLCN), the ...
ORGANISM(S): Caenorhabditis elegans 
2012-12-31 | E-GEOD-43207 | biostudies-arrayexpress
TranscriptomicsAnalysis of gene expression signatures in brown adipose tissue (BAT) following acute activation of AgRP neurons
We have found that acute activation of AgRP-neurons lead to inhibition of insulin-stimulated glucose uptake into BAT. Based on this finding, we asked whether this effect was accompanied by acute changes in gene expression, which could point to the mechanism(s) underlying the impaired insulin sensiti...
ORGANISM(S): Mus musculus 
2016-02-10 | E-GEOD-77766 | biostudies-arrayexpress
TranscriptomicsAltered lipid metabolism in the aging kidney identified by three layered omic analysis
Aging-related diseases and their comorbidities affect the life quality of a constantly growing proportion of our population. Age-associated changes of kidney structure and function are considerable contributors to the dramatically increased incidence of chronic kidney disease world-wide which has be...
ORGANISM(S): Mus musculus 
2015-10-30 | E-GEOD-74463 | biostudies-arrayexpress
TranscriptomicsA systems approach identifies progeroid Ercc1[-/Δ] mice as a model system for kidney aging.
Using these samples, it has been shown that the transcriptional landscape in glomeruli of Ercc1[-/Δ] mice at a rather young age of 14 weeks mimics that of mice which have undergone real-life renal aging. Thus, young Ercc1[-/Δ] mice can be used as a model system for glomerular aging in future studies...
ORGANISM(S): Mus musculus 
2012-12-21 | E-GEOD-43061 | biostudies-arrayexpress
TranscriptomicsDAF-16/FoxO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage [N2, xpa-1]
Genome maintenance defects cause complex disease phenotypes characterized by developmental failure, cancer susceptibility and premature aging. It remains poorly understood how DNA damage responses function during organismal development and maintain tissue functionality when DNA damage accumulates wi...
ORGANISM(S): Caenorhabditis elegans 
2014-11-18 | E-GEOD-51161 | biostudies-arrayexpress
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