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GenomicLocation and Function of Cytosine-5 Methylation in RNA

Mutations in the cytosine-5 RNA methyltransferase NSun2 can cause neurodevelopmental disorders and symptoms commonly found in patients with Dubowitz-like syndrome. Some tRNAs are known to be methylated NSun2, however the occurrence of cytosine-5 methylation (m5C) in other RNA biotypes ...

phs000645 | dbGaP
no omics definedTranscription profiling of primary mouse keratinocytes infected with Myc, MycV394D or control virus supernatants and treated with or without TGF beta 1 for 12 hours
Primary murine keratinocytes were infected with Myc, MycV394D or control virus supernatants and treated with or without TGF beta 1 for 12 hours. MycV394D is a Myc mutant, which does not bind Miz-1 anymore but is still able to bind to E-box sequences (Mol Cell 10:509-521, 2002).
ORGANISM(S): Mus musculus 
2005-12-20 | E-MEXP-497 | biostudies-arrayexpress
TranscriptomicsChIP-chip of wild_type and K14MycER in Mouse genome wide proximal promoter regions
Identification of c-Myc and H3K4me3 enriched genomic regions in normal or c-Myc overexpressed mouse epidermis
ORGANISM(S): Mus musculus 
2011-10-26 | E-MTAB-555 | biostudies-arrayexpress
TranscriptomicsChIP-chip of wild_type, K14MycER, K14Sin3afl/fl and K14Mycfl/fl in mouse whole genome Chr3
Identification of c-Myc, H3K4me3 and a set of skin differentiation specific TFs binding sites in the genome of normal or c-Myc overexpressed mouse epidermis
ORGANISM(S): Mus musculus 
2011-10-26 | E-MTAB-556 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of wild_type and K14MycER mice treated with tamoxifen in a time-course (0, 1, 2, 4 and 6 days)
Expression analysis of a c-Myc knockin effects on gene expression in adult mouse skin. We used an inducible system to overexpress c-Myc specifically in adult mouse K14 positive keratinocytes and analysed the resulting changes in gene expression by means of microarrays.
ORGANISM(S): Mus musculus 
2011-10-26 | E-MTAB-553 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling in skin of K14Sin3KO mice
Expression analysis of K14Sin3afl/flCreER,K14Mycfl/flCreER and K14Sin3aMycfl/flCreER effects on gene expression in adult mouse skin. We used a conditional knock out strategy to delete Sin3a and/or c-Myc specifically in adult mouse K14 positive keratinocytes and analysed the resulting changes in gene...
ORGANISM(S): Mus musculus 
2011-10-26 | E-MTAB-554 | biostudies-arrayexpress
TranscriptomicsSite-specific cytosine-5 methylation by the mouse RNA methyltransferases Dnmt2 and NSun2 promotes tRNA stability and protein synthesis
Mouse embryonic fibroblast (MEFs) cell lines and liver samples from Dnmt2 and Nsun2 single mutant, double mutant and wildtype mice were used to identify potential mRNA substrates of both proteins. MEFs were derived from day 13.5 embryos and immortalized by transfection with a plasmid expressing the ...
ORGANISM(S): Mus musculus 
2012-07-03 | E-GEOD-36918 | biostudies-arrayexpress
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