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ProteomicsProteomics of Fuchs Endothelial Corneal Dystrophy support that the extracellular matrix of Descemet¹s membrane is Disordered
Fuchs’ endothelial corneal dystrophy is major corneal disorder in the western world affecting the innermost part of the cornea, which leads to visual impairment. The morphological changes observed in Fuchs’ endothelial corneal dystrophy is well described, however, much less in known of the pathology...
ORGANISM(S): Homo sapiens (Human) 
2014-05-27 | PXD000746 | Pride
Itraq quantification Fuchs' endothelial corneal dystrophy Xic quantification 
GenomicsA Genome-Wide Association Study of Fuchs' Endothelial Corneal Dystrophy (FECD)

Fuchs' Endothelial Corneal Dystrophy (FECD) is a common disease that results in loss of vision associated with progressive corneal edema and loss of corneal transparency. In the initial stages of the disease, excrescences on Descemet's membrane with the appearance of an abnormal posterior...

phs000421.v1.p1 | EGA
OtherProteomics of Fuchs- Endothelial Corneal Dystrophy support that the extracellular matrix of Descemet-s membrane is disordered.
Data from ProteomeXchange, PXD ID: PXD000746. Experiment: label-free, file: 2012-10-05 - ETP - Fuchs - Control - 3-2.mgf. Published as part of J Proteome Res. 2014 May 21 . From the Abstract: {{i}} Fuchs- endothelial corneal dystrophy (FECD) is a major corneal disorder affecting the innermost part ...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310000394 | GPMDB
Resource Reanalysis 
ProteomicsProteomic analysis of Descemet's membrane with corneal endothelial cells derived from patients with Fuchs endothelial corneal dystrophy and healthy control subjects
This dataset contains proteomic profiles of Descemet's membrane (DM) with corneal endothelial cells derived from patients with Fuchs endothelial corneal dystrophy (FECD) and non-FECD subjects by shotgun proteomics. FECD is the most common inherited corneal disease. Fibrillar focal excrescences, call...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-17 | MSV000091078 | MassIVE
GenomicsRNA Misplicing in Fuchs Endothelial Corneal Dystrophy II
RNA Misplicing in Fuchs Endothelial Corneal Dystrophy II
PRJNA445238 | ENA
ProteomicsBlockade of mitochondrial components release by exosome pathway promotes the pathogenesis of Fuchs endothelial corneal dystrophy
Fuchs endothelial corneal dystrophy (FECD) is the leading indication of corneal transplantation worldwide and the focus of pathogenesis has been on the corneal endothelium. Instead of cellular analysis, we aimed to identify the protein changes of aqueous humor (AH) in patients with FECD and investig...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD065309 | Pride
Fuchs endothelial corneal dystrophy  proteomics  aqueous humor  corneal endothelium  mitochondrial quality control 
ProteomicsTCF4 trinucleotide repeat expansion drives distinct proteomic signatures in Fuchs endothelial corneal dystrophy
The aims of this study were to use an isogenic cell model system to investigate the proteomic consequences of TCF4 trinucleotide repeat expansion in Fuchs endothelial corneal dystrophy (FECD) and to identify potential molecular pathways contributing to disease pathogenesis. We used our previously es...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD075094 | Pride
Retina Fuchs endothelial corneal dystrophy (fecd) Ctg repeat 
GenomicsGene expression in Fuchs endothelial corneal dystrophy and healthy cultured cells
Gene expression in Fuchs endothelial corneal dystrophy and healthy cultured cells
PRJNA439004 | ENA
GenomicsTranscriptome analyses of human corneal endothelial cell lines derived from patients with Fuchs Endothelial Corneal Dystrophy
Transcriptome analyses of human corneal endothelial cell lines derived from patients with Fuchs Endothelial Corneal Dystrophy
PRJNA1201780 | ENA
GenomicsGene expression in Fuchs endothelial corneal dystrophy
Gene expression in Fuchs endothelial corneal dystrophy
PRJNA721087 | ENA
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