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GenomicsGAGA Factor maintains promoters in nucleosome-free conformation and allows promoter-proximal pausing [MNase]
Promoter-proximal pausing of RNA polymerase II (Pol II) is a widespread in higher eukaryotes. Previous studies have shown that GAF is enriched at paused genes, but the role of GAF in pausing has not been well characterized on a genome-wide level. To investigate the role of GAF in pausing, we RNAi-de...
ORGANISM(S): Drosophila melanogaster 
2015-04-04 | E-GEOD-58956 | biostudies-arrayexpress
TranscriptomicsFcp1 dephosphorylation of the RNA polymerase II C-terminal domain required for efficient transcription of heat shock genes
RNA polymerase II is decreased on heat shock-induced genes when the CTD phosphatase Fcp1 is knocked down in Drosophila S2 cells. We examined transcriptionally-engaged Pol II genome-wide with GRO-seq to determine if other genes are similarly affected. Two biological replicates of nascent RNA sequenci...
ORGANISM(S): Drosophila melanogaster 
2012-06-28 | E-GEOD-38748 | biostudies-arrayexpress
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