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MetabolomicsMetabolomic correlation-network modules in Arabidopsis based on a graph-clustering approach
Deciphering the metabolome is essential for a better understanding of the cellular metabolism as a system. Typical metabolomics data show a few but significant correlations among metabolite levels when data sampling is repeated across individuals grown under strictly controlled conditions. Although ...
2014-03-01 | MTBLS45 | MetaboLights
MetabolomicsMetabolomic Characterization of Knock-Out Mutants in Arabidopsis - Development of a Metabolite Profiling Database for Knock-Out Mutants in Arabidopsis (MeKO)
Despite recent intensive research efforts in functional genomics, the functions of only a limited number of Arabidopsis (Arabidopsis thaliana) genes have been determined experimentally. Thus, improving gene annotation remains a major challenge in plant science. Because metabolite profiling can chara...
2014-03-01 | MTBLS47 | MetaboLights
MetabolomicsUnbiased characterization of genotype-dependent metabolic regulations by metabolomic approach in Arabidopsis thaliana
Metabolites are not only the catalytic products of enzymatic reactions but also the active regulators or the ultimate phenotype of metabolic homeostasis in highly complex cellular processes. The modes of regulation at the metabolome level can be revealed by metabolic networks. We investigated the me...
2014-03-01 | MTBLS40 | MetaboLights
MetabolomicsA systems analysis with “simplified source-sink model” reveals metabolic reprogramming in a pair of source-to-sink organs during early fruit development in tomato by LED light treatments
Tomato (Solanum lycopersicum) is a model crop for studying development regulation and ripening in flesh fruits and vegetables. Supplementary light to maintain the optimal light environment can lead to the stable growth of tomatoes in greenhouses and areas without sufficient daily light integral. Tec...
2018-09-27 | MTBLS699 | MetaboLights
TranscriptomicsGene expression in aerial parts of rice-Arabidopsis Os-LBD37 FOX plants
Aerial parts of the rice-Arabidopsis FOX (Full-length cDNA overexpressor) lines K16331 and K19624 harboring the rice FL cDNA of LBD37 (Os-LBD37) were analyzed. LBD37 belongs to the plant- specific LOB- (Lateral Organ Boundary) domain family proteins first characterized in Arabidopsis. Results point ...
ORGANISM(S): Arabidopsis thaliana 
2009-12-26 | E-GEOD-14646 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of genes differentially expressed by oral carcinoma Ca9-22 and SLPI-deficient Ca9-22 (ΔSLPI) cells
We used the myoma model in conjunction with gene expression profiling with microarray data as an efficient tool for high throughput analysis and to screen for differentially expressed genes. Our aim was to identify candidates playing an important role in SLPI and/or MMP-promoted tumor invasion by co...
ORGANISM(S): Homo sapiens 
2016-08-22 | E-GEOD-78501 | biostudies-arrayexpress
MetabolomicsFruit setting rewires central metabolism via gibberellin cascades
Fruit set is the process whereby ovaries develop into fruits after pollination and fertilization. The process is induced by the phytohormone gibberellin (GA) in tomatoes, as determined by the constitutive GA response mutant procera However, the role of GA on the metabolic behavior in fruit-setting o...
2020-09-11 | MTBLS1892 | MetaboLights
TranscriptomicsMicroarray analysis of gene expression under different light conditions
The size of tomato fruits are largely dependent on growth conditions. To obtain insights on how light intensity contributes to translocation from a leaf and a fruit, we developed a plant irradiation system based on light-emitting diodes (LEDs) to a leaf. By using this system, we investigated the cha...
ORGANISM(S): Solanum lycopersicum 
2012-05-01 | E-GEOD-35020 | biostudies-arrayexpress
MetabolomicsDefective cytokinin signaling reprograms lipid and flavonoid gene-to-metabolite networks to mitigate high salinity in Arabidopsis

Cytokinin (CK) in plants regulates both developmental processes and adaptation to environmental stress. Arabidopsis histidine phosphotransfer ahp2,3,5 and type-B response regulator arr1,10,12 triple mutants are almost completely defective in CK signaling, and the ahp2,3,5

2021-11-25 | MTBLS2532 | MetaboLights
UnknownPhase 2 study of glucarpidase in patients with delayed methotrexate elimination after high-dose methotrexate therapy.
Not available
S-EPMC11258064 | biostudies-literature
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