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MetabolomicsFunctional Metabolomics Describes the Yeast Biosynthetic Regulome
Genome-metabolism interactions enable cell growth. To probe the extent of these interactions and delineate their functional contributions, we quantified the Saccharomyces amino acid metabolome and its response to systematic gene deletion. Over one-third of coding genes, in particular those important...
2017-03-02 | MTBLS434 | MetaboLights
MetabolomicsLinking root exudates to functional plant traits
Primary and secondary metabolites exuded by plant roots have mainly been studied under laboratory conditions, while knowledge of root exudate patterns of plants growing in natural communities is very limited. Focusing on ten common European grassland plant species, we asked to which degree exuded me...
2022-02-11 | MTBLS687 | MetaboLights
MetabolomicsLipidOA: A Machine-Learning and Prior-Knowledge-Based Tool for Structural Annotation of Glycerophospholipids
The Paternò-Büchi (PB) reaction is a carbon-carbon double bond (C═C)-specific derivatization reaction that can be used to pinpoint the location(s) of C═C(s) in unsaturated lipids and quantitate the location of isomers when coupled with tandem mass spectrometry (MS/MS). As the data of PB-MS/MS are in...
2022-11-23 | MTBLS6075 | MetaboLights
TranscriptomicsToward a functional annotation of the human genome using artificial transcription factors
Toward a functional annotation of the human genome using artificial transcription factors.
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-677 | biostudies-arrayexpress
MetabolomicsFunctional study of chicken seminal plasma based on metabolomics
By using metabolomics technology, the molecular changes of seminal plasma over time under 4°C liquid preservation conditions were analyzed, and candidate biomarkers related to the functional decline of semen were screened out.
2026-04-29 | MTBLS14407 | MetaboLights
MetabolomicsFunctional targeting of PTTG1 in pericytes restores vascular integrity in diabetic retina

Pericyte loss is an early and critical event in the pathogenesis of diabetic retinopathy (DR), yet the molecular mechanisms underlying pericyte dysfunction remain incompletely understood. Using single-cell RNA sequencing, we generated a retinal cellular overview comprising 18,926 cells from...

2026-03-27 | MTBLS13544 | MetaboLights
MetabolomicsMulti-omics and biophysical phosphoproteomics uncover functional phosphorylation networks of BRAFV600E-driven signaling

Dysregulated kinase activity drives oncogenic signalling, perturbs cellular homeostasis, and promotes tumour progression. Despite major success in targeting kinases therapeutically, the downstream consequences of kinase inhibition and the mechanisms underlying drug resistance remain incompletely ...

2025-12-09 | MTBLS7390 | MetaboLights
MetabolomicsFunctional specialization of bacterial cellular and extracellular fractions contributes to polysaccharide degradation

Bacteroides thetaiotaomicron (Bt), a key commensal of the human gut microbiota, exhibits robust capacity to degrade dietary polysaccharides via carbohydrate-active enzymes (CAZymes). However, the exact spatial distribution and the functional coordination of these enzymes remain poor...

2026-03-27 | MTBLS14156 | MetaboLights
MetabolomicsMetabolomics data from Lactiplantibacillus plantarum Probio87 intervention in adults with functional constipation

To evaluate the therapeutic potential of Lactiplantibacillus plantarum Probio87 in adults with functional constipation (FC), a randomized, double-blind, placebo-controlled trial was conducted. A total of 101 adults meeting the Rome IV diagnostic criteria for FC were enrolled. All participants rec...

2025-10-09 | MTBLS13105 | MetaboLights
MetabolomicsThe Cancer-Associated Microbe Library reveals functional host-microbe interactions during colorectal cancer progression

Functional characterization of microbes which colonize CRC is impeded by a lack of bacterial strains from tumor tissues. Here, we report the Cancer-Associated Microbe Library (CAM-L), comprising more than 3,000 viable bacterial isolates, representing 121 distinct species, and 60 matching organoid...

2026-02-08 | MTBLS7385 | MetaboLights
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