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MetabolomicsDifferentiation Defect Repositions Sebaceous Glands as Instigators in the Early Pathogenesis of Hidradenitis Suppurativa

The role of sebaceous glands (SGs) in the early pathogenesis of hidradenitis suppurativa (HS) is undefined, with unclear causal relationship to inflammatory sequelae. The aim of this study was to determine whether SG aberrations constitute a primary pathogenic driver in early HS and elucidate the...

2025-12-28 | MTBLS13578 | MetaboLights
MetabolomicsApplication of the Protease-Resistant Antimicrobial Peptide R7I, Composed of Natural Amino Acids, as a Functional Food Ingredient for Modulating Intestinal Health

Foodborne pathogenic bacterial infections pose significant challenges to global food safety and public health, while the issue of antimicrobial resistance (AMR) has worsened in recent years, creating an urgent need for safe, natural alternatives to combat foodborne pathogens and associated intest...

2025-11-09 | MTBLS13292 | MetaboLights
MetabolomicsMaize Recruits Beneficial Microorganisms via Rhizosphere Metabolites as Signals to Construct a Functional Network for Saline-Alkaline Stress Resistance

Carbonate-type saline-alkaline stress severely constrains maize production; however, the synergistic response mechanisms between rhizosphere microorganisms and metabolites remain unclear. This study focused on maize fields in the carbonate chernozem region of the Songnen Plain in Northeast China....

2026-06-08 | MTBLS13956 | MetaboLights
TranscriptomicsTranscription profiling of human hMADS cells during adipocyte and osteoblast differentiation
human adipocyte and osteoblast differentiation of hMADS cells
ORGANISM(S): Homo sapiens 
2008-08-08 | E-MARS-10 | biostudies-arrayexpress
TranscriptomicsFunctional diversity and convergence of small non-coding RNAs in male germ cell differentiation and fertilization (mRNA analysis)
The small non-coding RNAs (sncRNAs) are considered as postranscriptional key regulators of male germ cell development. In addition to microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs), other sncRNAs generated from small nucleolar RNAs (snoRNAs), tRNAs or rRNAs processing may also play important ...
ORGANISM(S): Mus musculus 
2015-03-26 | E-GEOD-59252 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic stem cell line Sox1Tv2 during neuronal differentiation
This experiment is part of the FunGenES project (FunGenES - Functional Genomics in Embryonic Stem Cells partially funded by the 6th Framework Programme of the European Union, http://www.fungenes.org). The experiment was conducted at Aventis Pharma, Paris, France. Goal of the experiment is the charac...
ORGANISM(S): Mus musculus 
2009-07-10 | E-TABM-669 | biostudies-arrayexpress
TranscriptomicsReversible and irreversible differentiation of cardiac fibroblasts
Aim: Differentiation of cardiac fibroblasts (Fb) into myofibroblasts (MyoFb) is responsible for connective tissue buildup in myocardial remodeling. We examined reversibility of MyoFb differentiation. Methods and Results: Adult rat cardiac Fb were cultured on a plastic substratum providing mechanical...
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-51824 | biostudies-arrayexpress
TranscriptomicsNotch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine
Dendritic cells (DCs) in tissues and lymphoid organs comprise distinct functional subsets that differentiate in situ from circulating progenitors. Tissue-specific signals that regulate DC subset differentiation are poorly understood. We report that DC-specific deletion of the Notch2 receptor caused ...
ORGANISM(S): Mus musculus 
2011-10-31 | E-GEOD-31551 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of mouse ESC cardiomyocyte-specific differentiation
The differentiation to cardiomyocytes is a prerequisite and an important part of heart development. A good understanding of the complicated cardiomyocyte differentiation process benefits cardiogenesis study. Embryonic stem cells (ESCs), cell lines with infinite ability to proliferate and to be diffe...
ORGANISM(S): Mus musculus 
2014-09-25 | E-GEOD-58300 | biostudies-arrayexpress
TranscriptomicsMicroarray profiling of monocytic differentiaion reveals miRNA-mRNA intrinsic correlation (gene expression)
Since the expression profile of miRNAs is specific in different tissues or under different physiological conditions, the correlations between miRNAs and mRNAs could vary under different biological circumstances. This is a study also used expression profiles of miRNA and mRNA during monocytic differe...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-26377 | biostudies-arrayexpress
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