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ProteomicsParallel kinase pathways stimulate actin polymerization at depolarized mitochondria
Mitochondrial damage (MtD) represents a dramatic change in cellular homeostasis, necessitating metabolic changes and stimulating mitophagy. One rapid response to MtD is rapid peri-mitochondrial actin polymerization, termed ADA (acute damage-induced actin). The activation mechanism for ADA is unknown...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-15 | PXD031699 | Pride
Rac gef Mefs Phosphoproteomics Actin Mitochondria Cdc42 gef 
MetabolomicsMetabolic phenotyping of urine from a dementia research cohort
To better understand the molecular mechanisms underpinning physiological variation in human populations, metabolic phenotyping approaches are increasingly being applied to studies involving hundreds and thousands of biofluid samples. Hyphenated ultra-performance liquid chromatography-mass spectromet...
2022-03-01 | MTBLS719 | MetaboLights
TranscriptomicsClaudin 1 mediates TNF alpha-induced gene expression and cell migration in human lung carcinoma cells
Epithelial-mesenchymal transition (EMT) is an important mechanism in carcinogenesis. To determine the mechanisms that are involved in the regulation of EMT is crucial to develop new biomarkers and therapeutic targets towards cancers. In this study, when TGFß1 and TNFa were used to induce EMT in hum...
ORGANISM(S): Homo sapiens 
2012-06-12 | E-GEOD-32254 | biostudies-arrayexpress
UnknownMitochondrial dysfunction triggers actin polymerization necessary for rapid glycolytic activation.
Not available
S-EPMC9477750 | biostudies-literature
UnknownPeri-mitochondrial actin filaments inhibit Parkin assembly by disrupting ER-mitochondria contacts.
Not available
S-EPMC12550048 | biostudies-literature
UnknownParallel kinase pathways stimulate actin polymerization at depolarized mitochondria.
Not available
S-EPMC9078333 | biostudies-literature
UnknownPeri-mitochondrial actin filament inhibit Parkin assembly via disruption of ER-mitochondrial contact
Not available
S-SCDT-10_1038-S44319-025-00561-Y | biostudies-other
UnknownSex differences in adenosine deaminase activity associate with disparities in SARS-CoV-2 innate immunity.
Not available
S-EPMC12059719 | biostudies-literature
TranscriptomicsExpression profiling of skin fibroblast, iPSC, iPSC-derived neural progenitors, and iPSC-derived neurons from Autism Spectrum Disorder male patients and their unaffected normal male siblings
Autism spectrum disorder (ASD) is an early onset neurodevelopmental disorder, which is characterized by disturbances of brain function and behavioral deficits in core areas of impaired reciprocal socialization, impairment in communication skills, and repetitive or restrictive interests and behaviors...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-GEOD-65106 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human biopsies of Nasopharyngeal carcinoma (NPC) and non-malignant controls
Nasopharyngeal carcinoma (NPC) is a common cancer in southern China and South East Asia where more than 50,000 new cases are diagnosed each year. We used microarrays to identify down or upregulated genes in NPC compared with non-malignant controls. Experiment Overall Design: Snap frozen nasopharynge...
ORGANISM(S): Homo sapiens 
2009-11-10 | E-GEOD-13597 | biostudies-arrayexpress
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