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MetabolomicsSymbiotic bacteria-derived organic acids protect Delia antiqua larvae from entomopathogenic fungal infection

The protection of associated microbiota for their animal hosts against pathogen infection has been studied widely over the last 100 years. However, how those microbes protect the animal host is limitedly investigated. In former studies, body surface microbes of one insect, Delia antiqua,...

2020-11-12 | MTBLS2074 | MetaboLights
MetabolomicsSurvival, gene and metabolite responses of Litoria verreauxii alpina frogs to fungal disease chytridiomycosis
The fungal skin disease chytridiomycosis has caused the devastating decline and extinction of hundreds of amphibian species globally, yet the potential for evolving resistance, and the underlying pathophysiological mechanisms remain poorly understood. We exposed 406 naïve, captive-raised alpine tree...
2018-01-09 | MTBLS457 | MetaboLights
MetabolomicsMetabolic profiling of Candida clinical isolates of different species and infection sources

Candida species are the most common cause of opportunistic fungal infections. Rapid identification and novel approaches for the characterization of these fungi are of great interest to improve the diagnosis and the knowledge about their pathogenic properties. This study aimed to characte...

2024-07-09 | MTBLS1978 | MetaboLights
MetabolomicsMining for natural product antileishmanials in a fungal extract library
Leishmaniasis is a Neglected Tropical Disease caused by the insect-vector borne protozoan parasite, Leishmania species. Infection affects millions of the World’s poorest, however vaccines are absent and drug therapy limited. Recently, public-private partnerships have developed to identify new modes ...
2021-02-12 | MTBLS868 | MetaboLights
MetabolomicsF1Fo-ATP synthase subunit determines lethal pathogenic fungi infection
Fungal infections, especially candidiasis and aspergillosis, claim an unacceptably high fatality rate. The energy ATP that is necessary for fungal cell growth and function is synthesized mainly through oxidative phosphorylation, with the key enzyme being F1Fo-ATP synthase. But it remains unknown how...
2021-10-08 | MTBLS3332 | MetaboLights
MetabolomicsA Metabolic Profiling Strategy for the Dissection of Plant Defense against Fungal Pathogens (GC-MS assay)
Here we present a metabolic profiling strategy employing direct infusion Orbitrap mass spectrometry (MS) and gas chromatography-mass spectrometry (GC/MS) for the monitoring of soybean's (Glycine max L.) global metabolism regulation in response to Rhizoctonia solani infection in a time-course. Key el...
2014-11-15 | MTBLS118 | MetaboLights
MetabolomicsMetabolomic Analysis of Candida albicans under Metal-based anti-fungal strategy

Based on a unique pathogen iron interplay mechanism, this work establishes a new therapeutic paradigm targeting iron homeostasis at the host-pathogen interface via sequential metabolic priming, offering a broadly applicable strategy to reprogram resource asymmetry and combat fungal infection.

2026-05-10 | MTBLS13715 | MetaboLights
MetabolomicsA Metabolic Profiling Strategy for the Dissection of Plant Defense against Fungal Pathogens (DI-MS assays)
Here we present a metabolic profiling strategy employing direct infusion Orbitrap mass spectrometry (MS) and gas chromatography-mass spectrometry (GC/MS) for the monitoring of soybean's (Glycine max L.) global metabolism regulation in response to Rhizoctonia solani infection in a time-course. Key el...
2014-11-15 | MTBLS117 | MetaboLights
MetabolomicsTargeting methionine synthase in a fungal pathogen causes a metabolic imbalance that impacts cell energetics, growth and virulence
There is an urgent need to develop novel antifungals to tackle the threat that fungal pathogens pose to human health. In this work, we have performed a thorough characterisation and validation of the promising target methionine synthase. We have uncovered that in Aspergillus fumigatus the absence of...
2020-10-15 | MTBLS1636 | MetaboLights
TranscriptomicsNew insight into a host-pathogen interaction unveiled by transcriptomics response of the global insect pest Plutella xylostella to a fungal pathogen
A genomic insight into how an insect pest responds to the infection of a fungal insect pathogen, such as Beauveria bassiana, is critical for alternative strategy of insect pest contol based on fungal insecticides but has not been well probed. Here we constructed three pairs of digital expression lib...
ORGANISM(S): Plutella xylostella 
2016-04-06 | E-GEOD-72383 | biostudies-arrayexpress
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