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MetabolomicsUntargeted metabolomics as a hypothesis-generation tool in plant protection product discovery: Highlighting the potential of trehalose and glycerol metabolism of fungal conidiospores as novel targets

INTRODUCTION: The production of high quality and safe food represents a main priority for the agri-food sector in the effort to sustain the exponentially growing human population. Nonetheless, there are major challenges that require the discovery of new, alternative, and improved...

2020-09-08 | MTBLS1565 | MetaboLights
MetabolomicsTargeting methionine synthase in a fungal pathogen causes a metabolic imbalance that impacts cell energetics, growth and virulence
There is an urgent need to develop novel antifungals to tackle the threat that fungal pathogens pose to human health. In this work, we have performed a thorough characterisation and validation of the promising target methionine synthase. We have uncovered that in Aspergillus fumigatus the absence of...
2020-10-15 | MTBLS1636 | MetaboLights
MetabolomicsDifferential alteration of plant functions by homologous fungal candidate effectors

Rust fungi are plant pathogens that cause epidemics which threatens the production of many important plant species, such as wheat, soy, coffee and poplar. Melampsora larici-populina (Mlp) causes the poplar rust and encodes at least 1184 candidate effectors (CEs), however their functions are poorl...

2020-12-03 | MTBLS2096 | MetaboLights
MetabolomicsMetabolic plasticity of lipid storage and utilization governs fungal persister formation within macrophages
The ability of Candida glabrata to survive within macrophages creates a reservoir for recurrent infections and antifungal failure, yet the underlying mechanisms remain elusive. Here, using a host-mimicking in vitro evolution model, we identify asparagine synthetase (ASN2) as a critical genetic deter...
2026-04-22 | MTBLS14351 | MetaboLights
MetabolomicsA single gene mutation underpins metabolic adaptation and acquisition of filamentous competence in the emerging fungal pathogen Candida auris

Filamentous cell growth is a vital property of fungal pathogens. The mechanisms of filamentation in the emerging multidrug-resistant fungal pathogen Candida auris are poorly understood. Here, we show that exposure of C. auris to glycerol triggers a rod-like filamentation-competent (RL-FC) phenoty...

2024-07-04 | MTBLS9053 | MetaboLights
TranscriptomicsFungal-Specific Transcription Factor AbPf2 Activates Pathogenicity in Alternaria brassicicola
Alternaria brassicicola is a successful saprophyte and necrotrophic plant pathogen. Molecular determinants of its life style shift between saprophyte and pathogen, however, are unknown. To identify these determinants we studied nonpathogenic mutants of a transcription factor-coding gene, AbPf2. F...
ORGANISM(S): Alternaria brassicicola 
2013-09-30 | E-GEOD-38984 | biostudies-arrayexpress
TranscriptomicsHuman Corneal microRNA Expression Profile in Fungal Keratitis
MicroRNAs (miRNAs) are small, stable non-coding RNA molecules with regulatory function and marked tissue specificity that post-transcriptionally regulate gene expression, however their role in fungal keratitis remain unknown. Our purpose was to identify the miRNAs in human cornea from fungal keratit...
ORGANISM(S): Homo sapiens 
2016-07-28 | E-GEOD-64843 | biostudies-arrayexpress
UnknownPhospholipase C-mediated calcium signalling is required for fungal development and pathogenicity in Magnaporthe oryzae.
Not available
S-EPMC6640429 | biostudies-literature
UnknownSystematic characterization of the peroxidase gene family provides new insights into fungal pathogenicity in Magnaporthe oryzae.
Not available
S-EPMC4488832 | biostudies-literature
TranscriptomicsGlobal Analysis of the Transcriptional Response of Whitefly to Entomopathogenic Fungi Beauveria bassiana Reveals New Insights on Host-Pathogen Interactions
We investigated the transcriptional response of invasive Mediterranean (MED) species of the whitefly B. tabaci complex (commonly referred to as Q biotype) to entomopathogenic fungi Beauveria bassiana using Illumina sequencing technology. Nearly 1,000 of control whiteflies, 48h fungal-induced whitefl...
ORGANISM(S): Bemisia tabaci 
2013-11-24 | E-GEOD-38108 | biostudies-arrayexpress
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