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TranscriptomicsWhole blood transcriptomics to define adaptive biochemical pathways of exercise during aging
The aim of the current study was to characterize the genetic adaptive pathways altered by exercise in veteran athletes and age-matched untrained individuals. Two groups of 50-60 year old males: competitive cyclists and untrained, minimally active individuals were examined. All participants completed...
ORGANISM(S): Homo sapiens 
2013-09-27 | E-GEOD-51216 | biostudies-arrayexpress
TranscriptomicsNatural compound screening
Transcriptional expression data for bioactive small molecules for mechanism identification. Keywords: Expression profiling by array MCF7 cells were treated with either NSC76022 (thaspine) or DMSO control for six hours, to identify compound specific gene regulation.
ORGANISM(S): Homo sapiens 
2009-10-04 | E-GEOD-13124 | biostudies-arrayexpress
TranscriptomicsExpression data from breast cancer FNA biopsies from patients (US samples)
This is Phase II Trial of 4courses of 5-fluorouracil, doxorubicin and cyclophosphamide follwed by 4 additional courses of weekly docetaxel and capecitabine administered as Preoperative Therapy for Patients with Locally Advanced Breast Cancer, Stages II and III by US oncology (PROTOCOL 02-103) We per...
ORGANISM(S): Homo sapiens 
2011-02-07 | E-GEOD-23988 | biostudies-arrayexpress
TranscriptomicsRIP-chip of HuR in MCF7 cells exposed to doxorubicin
The purpose of the study was to identify mRNA bound to HuR in the presence of doxorubicin in MCF7 cells. We collected cytoplasmic RNA from untreated and treated cells and detected differentially expressed genes (DEGs). We also coimmunoprecipitated HuR and IgG (as control) from doxorubicin treated ce...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-33055 | biostudies-arrayexpress
TranscriptomicsRegulation of interferon-inducible proteins by doxorubicin via IFN-alpha-JAK-STAT signaling in tumor cells
Activation of the immune system is a way for host tissue to defend itself against tumor growth. Hence, treatment strategies that are based on immunomodulation are on the rise. Conventional cytostatic drugs such as the anthracycline doxorubicin can also activate immune cell functions of macrophages a...
ORGANISM(S): Homo sapiens 
2012-05-22 | E-GEOD-30988 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome profiling by microarray of monocytes stimulated with LPS and treated with trabectedin, lurbinectedin or doxorubicin
In order to assess the potential difference on the effect of lurbinectedin on monocytes compared to trabectedin, which has a selective killing effect (Germano et al., 2013), we performed a whole transcriptome assay on monocytes from healthy donors stimulated with LPS and with either trabectedin or l...
ORGANISM(S): Homo sapiens 
2018-01-15 | E-MTAB-5366 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of rat heart tissue treated with saline or doxorubicin to identify molecular mechanisms of doxorubicin cardiac toxicity
Doxorubicin induces cardiomypathy in oncology patients. This study is aimed at identifying molecular mechanisms of doxorubicin cardiac toxicity in rats. Transcription profiling of heart tissue of rats treated with saline or doxorubicin 1, 2 or 3 mg/kg/week by iv once per week for 2, 4 or 6 weeks. So...
ORGANISM(S): Rattus norvegicus 
2012-07-01 | E-MTAB-1168 | biostudies-arrayexpress
TranscriptomicsParaoxonase 2 Serves a Proapopotic Function in Mouse and Human Cells in Response to the Pseudomonas aeruginosa Quorum-Sensing Molecule N-(3-oxododecanoyl)-Homoserine Lactone.
Pseudomonas aeruginosa use quorum-sensing molecules, including N-(3-oxododecanoyl)-homoserine lactone (C12), for intercellular communication. C12 activated apoptosis in mouse embryo fibroblasts (MEF) from both wild type (WT) and Bax/Bak double knock-out mice (WT MEF and DKO MEF that were responsive ...
ORGANISM(S): Mus musculus 
2015-02-14 | E-GEOD-65935 | biostudies-arrayexpress
TranscriptomicsHypoxia/Anoxia
The environment inside even a small tumor is characterized by total (anoxia) or partial oxygen deprivation, hypoxia. It has been shown that radiotherapy and some conventional chemotherapies may be less effective in hypoxia, and therefore it is important to investigate how different drugs act in diff...
ORGANISM(S): Homo sapiens 
2014-05-04 | E-GEOD-47009 | biostudies-arrayexpress
TranscriptomicsProlonged Drug Selection of Breast Cancer Cells and Enrichment of Cancer Stem Cell Characteristics.
Background: Cancer stem cells are presumed to have virtually unlimited proliferative and self-renewal abilities and to be highly resistant to chemotherapy, a feature that is associated with overexpression of ATP-binding cassette transporters. We investigated whether prolonged continuous selection of...
ORGANISM(S): Homo sapiens 
2011-09-25 | E-GEOD-24460 | biostudies-arrayexpress
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