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TranscriptomicsExpression data from CD4+ NaM-CM-/ve T cells under Treg-inducing condition in the presence or absence of butyrate
Commensal bacteria shapes gut immune system. Colonization bacteria increase the frequency of regulatory T cells, however, the molecular mechanisms has not yet been unknown. To reveal the mechanism, we isolated NaM-CM-/ve CD4+ T cells from spleen of C57BL/6 mice and cultured the cells under Treg-indu...
ORGANISM(S): Mus musculus 
2013-11-20 | E-GEOD-49619 | biostudies-arrayexpress
GenomicsGenome-wide measurement of acetylated histone H3 in naïve cells under Treg-inducing conditon
To investigate the molecular mechanism how butyrate promoter differentiation of naïve T cells into regulatory T cells Examination of acetylated histone H3 during the differentiation of regulatory T cells in the presence or absence of butyrate
ORGANISM(S): Mus musculus 
2013-11-20 | E-GEOD-49653 | biostudies-arrayexpress
GenomicsCommensal microbe-derived butyrate epigenetically induces colonic regulatory T cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-11-20 | E-GEOD-49655 | biostudies-arrayexpress
TranscriptomicsExpression data from CD4+ naïve T cells under Treg-inducing condition in the presence or absence of butyrate
Commensal bacteria shape the gut immune system. Colonization bacteria increase the frequency of regulatory T cells, however, the molecular mechanisms are not yet known. To reveal the mechanism, we isolated naïve CD4+ T cells from the spleen of C57BL/6 mice and cultured the cells under Treg-inducing ...
ORGANISM(S): Mus musculus 
2015-06-12 | E-GEOD-48045 | biostudies-arrayexpress
TranscriptomicsExpression profile of CXCR6 Hi T cells or CXCR6 Lo helper T cells in CD45Rb Hi tranfer model mice
To identify the role of chemokine receptor in inflammation of colon, we isolated CD3+CD4+ helper T cells harboring CXCR6 from colonic lamina propria of mice We used microarrays to identify the differentially expressed genes between CXCR6Hi Tcells and CXCR6Lo Tcells CXCR6 Hi or CXCR6 Lo T cells were ...
ORGANISM(S): Mus musculus 
2013-04-09 | E-GEOD-45881 | biostudies-arrayexpress
GenomicsGenome-wide measuement of methylated cytosin in regulatory T cells (Treg) and conventional T cells (Tconv) depleted with Uhrf1
To investigate the molecular mechanism how Uhrf1 regulate gene expression and cell cycle progression in Treg, we precipitated methylated DNA using recombinant MBD1 followed by genome-wide analysis of methylated gene loci by next generation sequencer Examination of methylated DNA in Treg and Tconv i...
ORGANISM(S): Mus musculus 
2014-04-07 | E-GEOD-56543 | biostudies-arrayexpress
TranscriptomicsExpression data from CD4+ T cells of germ free mice, SPF IQI mice and SPF C57BL/6 mice depletd with Uhrf1 (by Cd4Cre-Uhrf1flox/flox)
Commensal bacteria shapes gut immune system. Colonization bacteria increase the frequency of regulatory T cells, however, the molecular mechanisms has not yet been unknown. To reveal the mechanism, we isolated Treg cells and Non-Treg cells and performed the global expression analysis. Colonic lamina...
ORGANISM(S): Mus musculus 
2014-04-07 | E-GEOD-56542 | biostudies-arrayexpress
TranscriptomicsExpression data from T-bet deficient megakaryoerythroid progenitor (MEP) cells
RNA was harvested from T-bet deficient MEP cells versus "wild type" C57BL/6 control MEP cells freshly harvested from bone marrow. 3 samples in each group, representing MEP cells from three different T-bet deficient or control mice.
ORGANISM(S): Mus musculus 
2015-11-01 | E-GEOD-68943 | biostudies-arrayexpress
UnknownTheoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune tolerance.
Not available
S-EPMC6794947 | biostudies-literature
TranscriptomicsExpression data from CD4+ T cells of germ free mice, SPF IQI mice and SPF C57BL/6 mice depletd with Uhrf1
Commensal bacteria shapes gut immune system. Colonization bacteria increase the frequency of regulatory T cells, however, the molecular mechanisms has not yet been unknown. To reveal the mechanism, we isolated Treg cells and Non-Treg cells and performed the global expression analysis. Colonic lamin...
ORGANISM(S): Mus musculus 
2015-06-10 | E-GEOD-47818 | biostudies-arrayexpress
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