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ProteomicsStructural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis
The antibiotic resistance protein FusB rescues protein synthesis from inhibition by fusidic acid (FA), which locks elongation factor G (EF-G) to the ribosome after GTP hydrolysis. Here, we present time-resolved single-particle cryo-EM structures explaining the mechanism of FusB-mediated rescue. FusB...
ORGANISM(S): Staphylococcus aureus 
2025-05-07 | PXD062129 | Pride
Cryo-em Elongation factor g Ribosome Fusidic acid Fusb 
TranscriptomicsThe Fusidic acid Stimulon of Staphylococcus aureus
Genome-wide transcriptional profiling studies of the growth of bacteria with antimicrobial agents often reveals aspects of the drug-specific protective bacterial response. Fusidic acid is a steroid antimicrobial that inhibits protein synthesis by interfering with the release of elongation factor G (...
ORGANISM(S): Staphylococcus aureus 
2008-08-25 | GSE12210 | GEO
GenomicsSpread of the FAR-MRSA clone, a fusidic acid- and meticillin-resistant Staphylococcus aureus ST121, Europe
Spread of the FAR-MRSA clone, a fusidic acid- and meticillin-resistant Staphylococcus aureus ST121, Europe
PRJEB93889 | ENA
UnknownThe fusidic acid stimulon of Staphylococcus aureus.
Not available
S-EPMC2583067 | biostudies-literature
GenomicsStaphylococcus aureus
The Fusidic acid Stimulon of Staphylococcus aureus
PRJNA113721 | ENA
UnknownGenetic basis of resistance to fusidic acid in staphylococci.
Not available
S-EPMC1855526 | biostudies-literature
GenomicsEnterococcus faecalis OG1RF
Rifampicin and fusidic acid-resistant strain.
PRJNA20843 | ENA
UnknownExploration of the Fusidic Acid Structure Activity Space for Antibiotic Activity.
Not available
S-EPMC11820832 | biostudies-literature
TranscriptomicsResponse of Methicillin-resistant Staphylococcus aureus to Amicoumacin A
Methicillin resistant Staphylococcus aureus (MRSA) infection is becoming refractory to existing antibiotic therapy owing to the inherent ability of S. aureus to develop rapid resistance and is considered a major threat to public health. We found that a natural isolate of Bacillus pumilus from the C...
ORGANISM(S): Staphylococcus aureus 
2012-07-30 | E-GEOD-31342 | biostudies-arrayexpress
UnknownSkin Commensal Staphylococci May Act as Reservoir for Fusidic Acid Resistance Genes.
Not available
S-EPMC4651549 | biostudies-literature
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