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MetabolomicsHorizontal Transfer of Bacteriocin Biosynthesis Genes Requires Metabolic Adaptation To Improve Compound Production and Cellular Fitness

Biosynthetic gene clusters (BGCs) encoding the production of bacteriocins are widespread among bacterial isolates and are important genetic determinants of competitive fitness within a given habitat. Staphylococci produce a tremendous diversity of compounds, and the corresponding BGCs are frequen...

2022-11-09 | MTBLS5196 | MetaboLights
TranscriptomicsSingle-cell RNA-seq reveals activation of unique gene groups as a consequence of stem cell-parenchymal cell fusion
Fusion of donor mesenchymal stem cells with parenchymal cells of the recipient can occur in the brain, liver, intestine and heart following transplantation. The therapeutic benefit or detriment of resultant hybrids is unknown. Here we sought a global view of phenotypic diversification of mesenchym...
ORGANISM(S): Mus musculus 
2016-03-22 | E-GEOD-69926 | biostudies-arrayexpress
TranscriptomicsERK5 Regulates Muscle Cell Fusion through Klf Transcription Factors
In skeletal muscle differentiation, muscle-specific genes are regulated by two groups of transcription factors, the MyoD and MEF2 families, which work together to drive the differentiation process. Here we show that ERK5 regulates muscle cell fusion through Klf transcription factors. The inhibition ...
ORGANISM(S): Mus musculus 
2011-02-21 | E-GEOD-25827 | biostudies-arrayexpress
TranscriptomicsLarge scale screening for known fusion genes in cancer cell lines
We have utilized a version 2.0 of our Fusion gene microarray (version 1.0 described by PMID: 19152679 and GEO, GPL8078) to screen cancer cell lines for known fusion genes We assembled a comprehensive database of published fusion genes, including those which have been reported only in individual stud...
ORGANISM(S): Homo sapiens 
2011-02-10 | E-GEOD-24737 | biostudies-arrayexpress
TranscriptomicsLarge scale screening for fusion genes in sarcoma patient samples
We have utilized our custom array GPL11054 to screen a set of sarcoma patient samples for fusion genes One negative control was included in the study. We wanted to investigate the power of our fusion-gene array GPL11054 as a means for fusion gene detection in a series of sarcoma patient samples from...
ORGANISM(S): Homo sapiens 
2013-10-23 | E-GEOD-43632 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome analysis to detect fusion genes in pediatric BCP-ALL
Whole transcriptome RNA-seq of pediatric infant (<1year of aget at diagnosis) patients affected by B-cell precursor Acute Lymphoblastic leukemia (BCP-ALL). The aim of the study is to identify fusion gene rearrangements involved in childhood leukemia, using Next Generation Sequencing (NGS)
ORGANISM(S): Homo sapiens 
2021-10-25 | E-MTAB-9925 | biostudies-arrayexpress
GenomicsIdentifying Novel Fusion Genes in Myeloma
To identify novel fusion genes in Myeloma samples
EGAS00001000220 | EGA
TranscriptomicsRadical prostatectomy specimens with and without TMPRSS2:ERG fusion from 139 patients with prostate in a Toronto cohort
Prostate tumors with the gene fusion TMPRSS2:ERG have been reported to have a significantly higher risk of recurrence compared with tumors lacking the fusion. Tumors from 139 patients who underwent radical prostatectomy were analyzed for the expression of 502 cancer-related genes to identify genes d...
ORGANISM(S): Homo sapiens 
2009-10-22 | E-GEOD-18655 | biostudies-arrayexpress
GenomicsRARG fusion genes
RARG fusion genes
PRJNA1018491 | ENA
GenomicsFusion genes in EGFR mutant lung cancer
Fusion genes in EGFR mutant lung cancer
PRJNA755752 | ENA
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