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TranscriptomicsCleavage of NIK by the API2-MALT1 Fusion Oncoprotein Leads to Noncanonical NF-{kappa}B Activation
Proper regulation of nuclear factor κB (NF-κB) transcriptional activity is required for normal lymphocyte function, and deregulated NF-κB signaling can facilitate lymphomagenesis. We demonstrate that the API2-MALT1 fusion oncoprotein created by the recurrent t(11;18)(q21;q21) in mucosa-associated ly...
ORGANISM(S): Homo sapiens 
2011-01-30 | E-GEOD-25527 | biostudies-arrayexpress
TranscriptomicsThe human Ewing's Sarcoma oncoprotein EWS-FLI1 causes Ewing's-type tumors in zebrafish
The fusion oncoprotein EWS-FLI1 arises from a t(11;22)(q24;q12) chromosomal translocation and causes Ewing's Sarcoma, a malignant bone tumor. The mechanism whereby EWS-FLI1 transforms cells is unknown. Somatic, mosaic expression of human EWS-FLI1 in zebrafish from the heat shock promoter [Tg(HSP:...
ORGANISM(S): Danio rerio 
2011-11-01 | E-GEOD-31186 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse model for ETV6-NTRK3 (EN) fusion oncoprotein expresson
We report a mouse model that recapitulates expression of the ETV6-NTRK3 (EN) fusion oncoprotein, the product of the t(12;15)(p13;q25) translocation characteristic of human secretory breast carcinoma. Activation of EN expression in mammary tissues by Whey acidic protein (Wap) promoter-driven Cre lead...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9353 | biostudies-arrayexpress
GenomicsHarnessing the E3 ligase SPOP for targeted degradation of the NUP98::KDM5A fusion oncoprotein
Harnessing the E3 ligase SPOP for targeted degradation of the NUP98::KDM5A fusion oncoprotein
PRJNA1263808 | ENA
TranscriptomicsChromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip.
A global view of PML-RAR? transcriptional functions was obtained by genome-wide binding and chromatin modification analyses, combined with genome wide expression data. Complete Abstract: The translocation t(15;17) generates the chimeric PML-RAR? transcription factor that is the initiating event of ...
ORGANISM(S): Homo sapiens 
2008-09-06 | E-GEOD-12641 | biostudies-arrayexpress
GenomicsThe FUS-DDIT3 fusion oncoprotein inhibits BAF complex targeting and activity in myxoid liposarcoma
The FUS-DDIT3 fusion oncoprotein inhibits BAF complex targeting and activity in myxoid liposarcoma
PRJNA744758 | ENA
GenomicsFET fusion oncoprotein-regulated genes in HT1080 cell line
FET fusion oncoprotein-regulated genes in HT1080 cell line
PRJNA518039 | ENA
GenomicsThe Capicua C1 Domain is Required for Full Activity of the CIC::DUX4 Fusion Oncoprotein
The Capicua C1 Domain is Required for Full Activity of the CIC::DUX4 Fusion Oncoprotein
PRJNA1120911 | ENA
GenomicsThe Capicua C1 Domain is Required for Full Activity of the CIC::DUX4 Fusion Oncoprotein.
The Capicua C1 Domain is Required for Full Activity of the CIC::DUX4 Fusion Oncoprotein.
PRJNA1173224 | ENA
TranscriptomicsNSD3-NUT Fusion Oncoprotein in NUT Midline Carcinoma identified in 1221 patient-derived cell line by RNA-seq
Discarded live tumor tissue from a metastatic focus in the patientM-bM-^@M-^Ys lung was collected under institutional review board approval through the NUT midline carcinoma registry (www.NMCRegistry.org). From this tissue the first known NUT-variant cell line, 1221, was established. To determine th...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-57222 | biostudies-arrayexpress
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