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ProteomicsProximity interactions of Frizzled4 (FZD4) in the bEnd.3 mouse brain endothelial cell line
Frizzled4 (FZD4) is a pivotal molecule in the CNS vasculature and a target for therapeutic intervention. Little is known how FZD4 is regulated. A proximity biotinylation screen with FZD4 as bait in a mouse brain endothelial cell line was performed. The goal is to identify candidate regulators of FZD...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-14 | PXD077093 | Pride
GenomicsFOXF1 Promotes Tumor Vessel Normalization and Prevents Lung Cancer Progression through FZD4
FOXF1 Promotes Tumor Vessel Normalization and Prevents Lung Cancer Progression through FZD4
PRJNA1077324 | ENA
UnknownIdentification of Novel FZD4 Mutations in Familial Exudative Vitreoretinopathy and Investigating the Pathogenic Mechanisms of FZD4 Mutations.
Not available
S-EPMC10996936 | biostudies-literature
UnknownDecrease of FZD4 exon 1 methylation in probands from FZD4-associated FEVR family of phenotypic heterogeneity.
Not available
S-EPMC9638120 | biostudies-literature
TranscriptomicsFOXF1 Promotes Tumor Vessel Normalization and Prevents Lung Cancer Progression through FZD4
Cancer cells re-program normal lung endothelial cells (EC) into tumor-associated endothelial cells (TEC) that form leaky vessels supporting carcinogenesis. Transcriptional regulators that control reprogramming of EC into TEC are poorly understood. We identified Forkhead box F1 (FOXF1) as a critical ...
ORGANISM(S): Mus musculus 
2024-03-09 | GSE255969 | GEO
GenomicsTherapeutic modulation of the blood-brain barrier and ischemic stroke by a bioengineered FZD4-selective WNT surrogate
Therapeutic modulation of the blood-brain barrier and ischemic stroke by a bioengineered FZD4-selective WNT surrogate
PRJNA926592 | ENA
UnknownWhole-Gene Deletions of FZD4 Cause Familial Exudative Vitreoretinopathy.
Not available
S-EPMC8306649 | biostudies-literature
GenomicsRetinoic acid induced expression of Hnf1β and Fzd4 is required for pancreas development in Xenopus laevis
Retinoic acid induced expression of Hnf1β and Fzd4 is required for pancreas development in Xenopus laevis
PRJNA448780 | ENA
TranscriptomicsTherapeutic modulation of the blood-brain barrier and ischemic stroke by a bioengineered FZD4-selective WNT surrogate
Derangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in disorders ranging from stroke, cancer, diabetic retinopathy, and Alzheimer's disease. The Norrin/FZD4/TSPAN12 pathway activates WNT/-catenin signaling, which is essential for BBB and BRB function. However, systemi...
ORGANISM(S): Mus musculus 
2023-01-31 | GSE223498 | GEO
GenomicsTherapeutic modulation of the blood-brain barrier and ischemic stroke by a bioengineered FZD4-selective WNT surrogate (bulk)
Therapeutic modulation of the blood-brain barrier and ischemic stroke by a bioengineered FZD4-selective WNT surrogate (bulk)
PRJNA926996 | ENA
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