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TranscriptomicsThe G Protein-coupled Receptor P2Y14 Influences Insulin Release and Smooth Muscle Function in Mice
UDP-sugars were identified as extracellular signaling molecules, assigning a new function to these compounds in addition to their well defined role in intracellular substrate metabolism and storage. Previously regarded as an orphan receptor, the G protein-coupled receptor (GPCR) P2Y14 (GPR105) was f...
ORGANISM(S): Mus musculus 
2014-07-11 | E-GEOD-59285 | biostudies-arrayexpress
GenomicsTherapeutic Activation of G Protein-Coupled Estrogen Receptor 1 in Waldenström Macroglobulinemia
Therapeutic Activation of G Protein-Coupled Estrogen Receptor 1 in Waldenström Macroglobulinemia
PRJNA855909 | ENA
ProteomicsStromal Interaction Molecule 1 Maintains Beta Cell Identity and Function in Female Mice through Preservation of G Protein-Coupled Estrogen Receptor 1 Signaling
Loss of pancreatic Beta cell mass, identity, and function contribute to the development of diabetes. Here, we show that the endoplasmic reticulum (ER) calcium sensor, stromal interaction molecule 1 (STIM1), is critical for the maintenance of Beta cell function in female mice. When mice with Beta cel...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2022-07-20 | MSV000089927 | MassIVE
ProteomicsIdentification of cytoplasmic proteins interacting with unliganded estrogen receptor α and β- in human breast cancer cells
Estrogen Receptor subtypes (ERα and ERβ) are transcription factors sharing similar structure, however, they often perform opposite roles in breast cancer’s cell proliferation and tumor progression. Besides the well-characterized genomic actions of ERs upon ligand binding, rapid non-genomic cytoplasm...
ORGANISM(S): Homo sapiens (Human) 
2015-03-11 | PXD001202 | Pride
Estrogen receptor Tap-tag Lc-ms/ms 
GenomicsPharmacologic activation of G protein-coupled estrogen receptor inhibits pancreatic ductal adenocarcinoma
Pharmacologic activation of G protein-coupled estrogen receptor inhibits pancreatic ductal adenocarcinoma
PRJNA481745 | ENA
GenomicsRegulatory mechanisms of the Hippo/YAP axis by G-protein coupled estrogen receptor in gastric signet-ring cell carcinoma
Regulatory mechanisms of the Hippo/YAP axis by G-protein coupled estrogen receptor in gastric signet-ring cell carcinoma
PRJNA1191875 | ENA
UnknownG protein-coupled estrogen receptor protects from atherosclerosis.
Not available
S-EPMC4274506 | biostudies-literature
UnknownG Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell Polarization.
Not available
S-EPMC7649801 | biostudies-literature
TranscriptomicsTherapeutic Activation of G Protein-Coupled Estrogen Receptor 1 in Waldenström Macroglobulinemia
Activation of G protein-coupled estrogen receptor 1 (GPER1) is an attractive therapeutic strategy to treat a variety of human diseases, including cancer. Here, we show that GPER1 is remarkably upregulated in tumor cells derived from different cohorts of Waldenström Macroglobulinemia (WM) patients re...
ORGANISM(S): Homo sapiens 
2024-07-01 | GSE207488 | GEO
UnknownThe G Protein-Coupled Estrogen Receptor Agonist G-1 Inhibits Nuclear Estrogen Receptor Activity and Stimulates Novel Phosphoproteomic Signatures.
Not available
S-EPMC4880142 | biostudies-literature
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