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GenomicsG-Quadruplex structures are stable and detectable in human genomic DNA.
The G-quadruplex is an alternative DNA structural motif that is considered to be functionally important in the mammalian genome. Herein, we address the hypothesis that G-quadruplex structures can exist within double-stranded genomic DNA using a G-quadruplex-specific probe. An engineered antibody is ...
ORGANISM(S): Homo sapiens 
2013-05-08 | E-GEOD-45241 | biostudies-arrayexpress
TranscriptomicsAltered gene expression in Werner & Bloom syndromes is associated with sequences having G-quadruplex forming potential
The human Werner and Bloom syndromes (WS and BS) are caused by deficiencies in the WRN and BLM RecQ helicases, respectively. WRN, BLM and their S. cerevisiae homologue Sgs1, are particularly active in vitro in unwinding G-quadruplex DNA (G4-DNA), a family of non-canonical nucleic acid structures fo...
ORGANISM(S): Homo sapiens 
2009-12-09 | E-GEOD-19205 | biostudies-arrayexpress
GenomicsProfiling DNA G-quadruplex structures at single-cell level
Profiling DNA G-quadruplex structures at single-cell level
PRJNA751854 | ENA
GenomicsG-quadruplex structures moulds the DNA methylome
G-quadruplex structures moulds the DNA methylome
PRJNA421087 | ENA
GenomicsA SNF2 protein targets variable copy number repeats and thereby influences allele-specific expression
ATRX is an X-linked gene of the SWI/SNF family whose role in vivo is currently unknown. Mutations in ATRX cause syndromal mental retardation. ATRX binds to tandem repeat (TR) sequences both in heterochromatin (e.g. telomeres) and euchromatin. Genes associated with these TRs can be dysregulated when ...
ORGANISM(S): Homo sapiens 
2010-11-02 | E-GEOD-22162 | biostudies-arrayexpress
TranscriptomicsG-quadruplex structures mark human regulatory chromatin
DNA secondary structures are important for fundamental genome functions such as transcription and replication1. The G-quadruplex (G4) structural motif has been linked to gene regulation2,3 and genome instability4,5 and may be important to cancer development and other diseases6-8. Recently, ~700,000 ...
ORGANISM(S): Homo sapiens 
2016-08-05 | E-GEOD-76688 | biostudies-arrayexpress
GenomicsGenome-wide mapping of G-quadruplex structures with CUT&Tag
Genome-wide mapping of G-quadruplex structures with CUT&Tag
PRJNA723824 | ENA
GenomicsG-quadruplex stabilization
The effect of prolonged G-quadruplex stabilization on the functions of human cells
PRJEB85998 | ENA
GenomicsG-Quadruplex structures are stable and detectable in human genomic DNA.
The G-quadruplex is an alternative DNA structural motif that is considered to be functionally important in the mammalian genome. Herein, we address the hypothesis that G-quadruplex structures can exist within double-stranded genomic DNA using a G-quadruplex-specific probe. An engineered antibody is ...
ORGANISM(S): Homo sapiens 
2013-05-08 | GSE45241 | GEO
GenomicsControl of cellular translation by endogenous RNA G-quadruplex structures
Control of cellular translation by endogenous RNA G-quadruplex structures
PRJNA673726 | ENA
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