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TranscriptomicsRNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer
The translational control of oncoprotein expression is implicated in many cancers. Here we report an eIF4A/DDX2 RNA helicase-dependent mechanism of translational control that contributes to oncogenesis and underlies the anticancer effects of Silvestrol and related compounds. For example, eIF4A promo...
ORGANISM(S): Homo sapiens 
2014-07-27 | E-GEOD-56887 | biostudies-arrayexpress
GenomicsG-Quadruplex structures are stable and detectable in human genomic DNA.
The G-quadruplex is an alternative DNA structural motif that is considered to be functionally important in the mammalian genome. Herein, we address the hypothesis that G-quadruplex structures can exist within double-stranded genomic DNA using a G-quadruplex-specific probe. An engineered antibody is ...
ORGANISM(S): Homo sapiens 
2013-05-08 | E-GEOD-45241 | biostudies-arrayexpress
GenomicsGlobal analyses of RNA G-quadruplexes
Global analyses of RNA G-quadruplexes
PRJNA326510 | ENA
GenomicsNative G-quadruplexes Stabilization Impairs Transcription Initiation
Native G-quadruplexes Stabilization Impairs Transcription Initiation
PRJNA739982 | ENA
GenomicsGenome-wide profiling of DNA G-quadruplexes in living neurons
Genome-wide profiling of DNA G-quadruplexes in living neurons
PRJNA789551 | ENA
GenomicsNative G-quadruplexes Stabilization Impairs Transcription Initiation
G-quadruplexes (G4s) are noncanonical DNA secondary structures formed through the self-association of guanines. They are distributed genome-widely and participate in multiple biological processes including gene transcription, and quadruplex-targeted ligands serve as potential therapeutic agents for ...
ORGANISM(S): Homo sapiens 
2021-07-19 | GSE178668 | GEO
GenomicsWhole genome mapping of DNA G-quadruplexes in multiple species by G4-seq
Whole genome mapping of DNA G-quadruplexes in multiple species by G4-seq
PRJNA434023 | ENA
OtherGlobal analyses of RNA G-quadruplexes
In vitro, some RNAs can form stable four-stranded structures known as G-quadruplexes. Although RNA G-quadruplex structures have been implicated in post-transcriptional gene regulation and diseases, direct evidence for quadruplex formation in cells has been lacking. Here, we developed a suite of meth...
ORGANISM(S): Mus musculus Parasynechococcus marenigrum WH 8102 Pseudomonas putida Saccharomyces cerevisiae Homo sapiens Escherichia coli 
2016-09-24 | GSE83617 | GEO
GenomicsDNA G-quadruplexes are transcription factor binding hot spots in human chromatin
DNA G-quadruplexes are transcription factor binding hot spots in human chromatin
PRJNA606017 | ENA
GenomicsRNA-seq of rat nucleus pulposus cells after stabilizing G-Quadruplexes
RNA-seq of rat nucleus pulposus cells after stabilizing G-Quadruplexes
PRJNA798742 | ENA
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