Sort   by:  
 Page size 
MetabolomicsATG9A-PLA2G6 axis reprograms phospholipid metabolism to drive metabolic liver disease and hepatocellular carcinoma

The liver orchestrates systemic metabolism, and its dysfunction drives diseases including metabolic dysfunction-associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC). ATG9A, an autophagy-related transmembrane protein and lipid scramblase, regulates lipid dynamics, yet its ...

2025-10-24 | MTBLS12451 | MetaboLights
GenomicsThe Histone H3 Lysine 9 Methyltransferases G9a and GLP Regulate Polycomb Repressive Complex 2-Mediated Gene Silencing [ChIP-Seq]
G9a/GLP and Polycomb Repressive Complex 2 (PRC2) are two major epigenetic silencing machineries, which in particular methylate histone H3 on lysines 9 and 27 (H3K9 and H3K27), respectively. Although evidence of a crosstalk between H3K9 and H3K27 methylations has started to emerge, their actual inter...
ORGANISM(S): Mus musculus 
2014-01-03 | E-GEOD-46536 | biostudies-arrayexpress
TranscriptomicsG9a selectively represses a class of late-replicating genes at the nuclear periphery (Expression)
We have investigated the role of the histone methyltransferase G9a in the establishment of silent nuclear compartments. Following conditional knockout of the G9a methyltransferase in mouse ESCs, 167 genes were significantly up-regulated, and no genes were strongly down-regulated. A partially overlap...
ORGANISM(S): Mus musculus 
2010-06-20 | E-GEOD-18076 | biostudies-arrayexpress
TranscriptomicsG9a-dependent gene expression in mouse AML cells
The methyltransferase G9a was found to play a role in the disease progression of a murine model of AML. Mouse HSPCs were transformed with HoxA9/Meis1 and treated with G9a/GLP inhibitor UNC0638. We used microarrays to detail the global program of gene expression that depends on the methyltransferase ...
ORGANISM(S): Mus musculus 
2014-01-08 | E-GEOD-53894 | biostudies-arrayexpress
TranscriptomicsG9a selectively represses a class of late-replicating genes at the nuclear periphery (WG_CGH)
We have investigated the role of the histone methyltransferase G9a in the establishment of silent nuclear compartments. Following conditional knockout of the G9a methyltransferase in mouse ESCs, 167 genes were significantly up-regulated, and no genes were strongly down-regulated. A partially overlap...
ORGANISM(S): Mus musculus 
2009-11-02 | E-GEOD-18079 | biostudies-arrayexpress
TranscriptomicsThe Histone H3 Lysine 9 Methyltransferases G9a and GLP Regulate Polycomb Repressive Complex 2-Mediated Gene Silencing [RNA-Seq]
G9a/GLP and Polycomb Repressive Complex 2 (PRC2) are two major epigenetic silencing machineries, which in particular methylate histone H3 on lysines 9 and 27 (H3K9 and H3K27), respectively. Although evidence of a crosstalk between H3K9 and H3K27 methylations has started to emerge, their actual inter...
ORGANISM(S): Mus musculus 
2014-01-03 | E-GEOD-49669 | biostudies-arrayexpress
TranscriptomicsG9a influences neuronal subtype specification in striatum
Cocaine-mediated repression of the histone methyltransferase (HMT) G9a has recently been implicated in transcriptional, morphological, and behavioral responses to chronic cocaine administration. Here, using a ribosomal affinity purification approach, we find that G9a repression by cocaine occurs in ...
ORGANISM(S): Mus musculus 
2014-02-05 | E-GEOD-54656 | biostudies-arrayexpress
GenomicsG9a/GLP-dependent H3K9me2 patterning alters chromatin structure at CpG islands in hematopoietic progenitors.
We profiled chromatin accessibility across the genome of HSPCs treated with either a small molecule inhibitor of G9a/GLP or DMSO. We observed that chromatin accessibility is dramatically altered at the regions of H3K9me2 nucleation. We have characterized the regions of H3K9me2 nucleation, revealing ...
ORGANISM(S): Homo sapiens 
2014-09-25 | E-GEOD-59749 | biostudies-arrayexpress
ProteomicsG9a/GLP inhibition during ex vivo lymphocyte expansion increases in vivo cytotoxicity of engineered TCR-T cells against hepatocellular carcinoma
Engineered T cells transiently expressing tumor-targeting receptors are an attractive form of engineered T cell therapy as they carry no risk of insertional mutagenesis or long-term adverse side-effects. However, multiple rounds of treatment are often required, increasing patient discomfort and cost...
ORGANISM(S): Homo Sapiens (human) 
2023-01-19 | PXD039542 | JPOST Repository
ProteomicsFunctional proteomics defines a PRC2-G9A interaction network and reveals ZNF518B as a G9A regulator
Not available
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2014-12-17 | MSV000078980 | MassIVE
Sort   by:  
 Page size